Persistent throat soreness and itching despite treatment may have several causes. One common reason is laryngopharyngeal reflux, in which acid from the stomach irritates the throat even when heartburn is not present. Other possible causes include chronic throat inflammation, post-nasal drip from allergies or sinus problems, dryness from mouth breathing, or irritation from past use of pan masala, which may take time to heal completely. Less commonly, fungal infection or vitamin deficiencies may also contribute. Since your symptoms have persisted despite taking Rebagen (Rebamipide), antacids, and Lycored (Selenium, Zinc, and Lycopene), further evaluation is needed. You should consult an ENT doctor for a detailed throat examination and, if required, a flexible laryngoscopy to examine the throat and voice box. In the meantime, continue avoiding irritants such as smoking, pan masala, spicy foods and alcohol. Drink plenty of water, maintain good oral hygiene, and avoid clearing your throat repeatedly. If reflux is suspected, lifestyle measures such as eating smaller meals and avoiding lying down soon after eating may also help.