For kidney stones of this size, especially the 21mm and 22mm stones in your right kidney and the 11mm stones in your left, medication alone cannot dissolve or pass them. These large stones require active urological intervention, such as lithotripsy, ureteroscopy, or percutaneous nephrolithotomy (PCNL). To manage your back pain temporarily, over-the-counter pain relievers like ibuprofen or acetaminophen can help, but you must consult a urologist immediately. They will prescribe stronger pain management if needed and recommend the appropriate procedure to safely remove the stones and prevent kidney damage.