For mild muscle stiffness, over-the-counter pain relievers like ibuprofen (an NSAID) or acetaminophen can help reduce discomfort. If the stiffness is accompanied by painful spasms, a doctor may prescribe muscle relaxants such as cyclobenzaprine or methocarbamol. For chronic conditions like arthritis, specific targeted therapies may be necessary. Because medications have potential side effects and can interact with other drugs, it is crucial to consult a healthcare professional for a proper diagnosis and prescription. Additionally, supportive measures like gentle stretching, warm compresses, and staying well-hydrated are highly recommended.