To lower high triglycerides, lifestyle changes like diet and exercise are the first steps. If medication is needed, your doctor may prescribe Fibrates (e.g., fenofibrate), which are highly effective at lowering triglyceride levels. Prescription Omega-3 Fatty Acids (e.g., Vascepa): High-dose, purified fish oils that reduce triglyceride production in the liver. Statins, e.g., atorvastatin): Primarily used for cholesterol, but they also moderately lower triglycerides and reduce overall cardiovascular risk. Niacin: Less commonly used now, but can lower triglycerides.\n\nPlease consult your healthcare provider to determine the safest medication and dosage based on your specific health profile.