About CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN
CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is a combination medication indicated for the management of neuropathic pain associated with diabetic neuropathy, post-herpetic neuralgia (damage to the nerve fibres during shingles infection), pain in fibromyalgia (musculoskeletal pain) or spinal cord injury. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system.
CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN contains Pregabalin, Nortriptyline, Methylcobalamin, and Cholecalciferol. Pregabalin is an antiepileptic agent/anticonvulsant that affects the chemicals in the brain that send pain signals across the nervous system, thereby relieving nerve pain. Nortriptyline (antidepressant) works by increasing neurotransmitters (serotonin and noradrenaline) in the brain, thus reducing the pain signals in the brain. Mecobalamin/Methylcobalamin, a form of vitamin B12, regulates body functions, such as cell multiplication, blood formation, and protein synthesis. Cholecalciferol/Vitamin D3 promotes a neuroprotective effect and prevents the progression of nerve damage.
Your doctor will decide the dosage based on your medical condition. Sometimes, CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may have common side effects like dizziness, drowsiness, blurred vision, shakiness, headache, nausea, vomiting, constipation, weight gain, swelling in the hands and feet, and dry mouth. These side effects do not require medical attention and gradually resolve over time. However, talk to your doctor if you experience these side effects persistently.
Please tell your doctor if you are allergic to CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN or its components. Let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother. CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it could lead to increased dizziness and sleepiness. Safety and efficacy of CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN have not been established in patients younger than 18 years.
Uses of CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN
Neuropathy, pain in fibromyalgia (musculoskeletal pain), and nerve pain in post-herpetic neuralgia (damage to the nerve fibres during shingles infection).
Medicinal Benefits
CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN contains Pregabalin, Nortriptyline, Methylcobalamin, and Cholecalciferol. Pregabalin works by binding to the specific site on voltage-gated calcium channels, thus helping to relieve nerve pain. Nortriptyline increases the levels of nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Methylcobalamin regulates body functions, such as cell multiplication, blood formation, and protein synthesis. Cholecalciferol promotes a neuroprotective effect and prevents the progression of nerve damage.
Directions for Use
Storage
Side Effects of CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN
- Dizziness
- Drowsiness
- Blurred vision
- Shakiness
- Headache
- Nausea
- Vomiting
- Constipation
- Weight gain
- Swelling in the hands and feet
- Dry mouth
In-Depth Precautions and Warning
Drug Warnings
Let your doctor know if you have any blood disorders, chronic obstructive pulmonary disease (COPD), liver/kidney/heart diseases, diabetes, mood disorders, schizophrenia, thyroid problems, glaucoma, Brugada syndrome (a genetic heart condition), fits, substance use disorder, angioedema (painless swelling under the skin) or receiving electroconvulsive treatment before starting CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN. Pregnant and breastfeeding women should consult their doctor before taking CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN. This medicine may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol during the treatment, as it could increase dizziness and sleepiness. CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN should not be given to children as safety and effectiveness have not been established.
Drug Interactions
Drug-Drug Interaction: CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may interact with painkillers (codeine, hydrocodone), anti-anxiety drugs (diazepam, alprazolam), antidepressants (duloxetine), thyroid medicines (levothyroxine), muscle relaxants (carisoprodol, cyclobenzaprine), anti-allergic drugs (cetirizine), common cold medicines (diphenhydramine), anti-emetics (ondansetron), and antipsychotics (olanzapine, quetiapine).
Drug-Food Interaction: Avoid consumption of alcohol while taking CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it might cause increased dizziness and sleepiness.
Drug-Disease Interaction: Inform your doctor if you have blood disorders, chronic obstructive pulmonary disease (COPD), liver/kidney/heart diseases, diabetes, mood disorders, schizophrenia, thyroid problems, glaucoma, Brugada syndrome, fits, substance use disorder, angioedema or receiving electroconvulsive treatment before starting CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consumption of alcohol while taking CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it may cause increased dizziness and sleepiness.
Pregnancy
cautionCHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN should be used during pregnancy only when advised by your doctor. Let your doctor know if you are pregnant or planning to conceive before taking CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN.
Breast Feeding
cautionPlease consult your doctor before taking this medicine; your doctor will decide whether CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN can be taken by breastfeeding mothers or not.
Driving
unsafeCHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN causes dizziness, drowsiness, and blurred vision and may interfere with your driving ability. Do not drive or operate machinery if you are not mentally alert and focused.
Liver
cautionLet your doctor know if you have any history of liver diseases before taking CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN. Your doctor may adjust the dose if necessary based on your condition.
Kidney
cautionLet your doctor know if you have any history of kidney diseases before taking CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN. Your doctor may adjust the dose if necessary based on your condition.
Children
unsafeSafety and efficacy of CHOLECALCIFEROL+METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN have not been established in patients younger than 18 years.
Habit Forming
Diet & Lifestyle Advise
- Try Vitamin B complex food sources like milk, cheese, eggs, liver and kidney, chicken, red meat, tuna, mackerel, salmon, shellfish, oysters, clams, dark green vegetables, such as spinach and kale, beets, avocados, potatoes, whole grains, cereals, kidney beans, black beans, and chickpeas.
- Include cayenne pepper in your diet to help lower neuropathic pain.
- Taking a warm shower can help ease the pain.
- Avoid smoking and alcohol consumption.
- Using essential oils for massage can help increase circulation.
- Exercise regularly and maintain a healthy lifestyle. Avoid excess fatty foods.
Patients Concern
Disease/Condition Glossary
Neuropathic pain: It is a nervous disorder that occurs due to nerve damage caused by chronic progressive nerve disease, limb amputation, diabetes or due to infection or injury. The pain could be intermittent or continuous, such as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensation is also common with neuropathic pain. Symptoms include spontaneous, un-triggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).
