Clindamycin+clotrimazole+tinidazole
About Clindamycin+clotrimazole+tinidazole
Clindamycin+clotrimazole+tinidazole is used to treat vaginal infections caused by bacteria (bacterial vaginosis), yeast infection (candidiasis), and parasitic infections (trichomoniasis). Bacterial vaginosis is caused by the change in the average balance of vaginal bacteria. Vaginal yeast infection or Candidiasis is the infection of the vagina and tissues at the opening of the vagina (vulva). Trichomoniasis is a sexually transmitted infection caused by a parasite. Symptoms of a vaginal infection include itching, odour, and abnormal heavy white discharge from the vagina.
Clindamycin+clotrimazole+tinidazole comprises three medicines: 'Clindamycin' (antibiotic), 'Clotrimazole' (antifungal), and 'Tinidazole'. Clindamycin belongs to the lincomycin antibiotic group that inhibits bacterial protein synthesis, which is required for the bacteria's survival. Tinidazole is an antibiotic or antiprotozoal which kills amoeba and parasites. On the other hand, Clotrimazole belongs to the imidazole antifungal group that kills fungi by causing holes in their cell membrane, thereby leaking all content.
Common side effects of Clindamycin+clotrimazole+tinidazole include a burning sensation, irritation, and itching in the vaginal area. However, these side effects are mild and temporary in nature. Consult the doctor if the side effects persist or worsen.
Inform your doctor if you are allergic to any antibacterial, antifungal, clotrimazole, clindamycin, or any of its components. It is essential to tell your doctor if you use any other azole antifungal or lincomycin antibiotic agents before using Clindamycin+clotrimazole+tinidazole; otherwise, using other antifungal or antibacterial may lead to overdose and toxicity. Let your doctor know if you have any liver, kidney, and gastrointestinal diseases (diarrhoea and colitis, an inflammation of the colon), allergic conditions (asthma, hay fever, eczema), diabetes, and immune system problems (HIV-AIDS). Clotrimazole and mineral oil additives in Clindamycin+clotrimazole+tinidazole may weaken rubber products' activities of contraceptive devices, latex condoms, diaphragms, and cervical caps. Sometimes, antibiotic medications can cause antibiotic resistance. In such cases, your doctor may prescribe other antibiotics you are not resistant to.
Uses of Clindamycin+clotrimazole+tinidazole
• Restoration of Vaginal Flora: Clindamycin+clotrimazole+tinidazole helps to treat vaginal infections by restoring healthy bacteria, reducing symptoms, and effectively managing mixed bacterial, fungal, and parasitic infections.
• Treatment of Bacterial Vaginosis: Clindamycin+clotrimazole+tinidazole can help treat bacterial vaginosis symptoms like unusual discharge and odor.
• Fungal vaginal infections: Clindamycin+clotrimazole+tinidazole is often prescribed to treat fungal vaginal infections like candidiasis (yeast infections), helping to alleviate symptoms such as itching, burning, and discharge.
• Improving Vaginal Health: Regular use of Clindamycin+clotrimazole+tinidazole promote beneficial bacteria growth, supporting overall vaginal health and reducing infection risk.
Medicinal Benefits
Clindamycin+clotrimazole+tinidazole is used to treat vaginal infections like bacterial vaginosis (BV), candidiasis, and trichomoniasis. It comprises three medicines: 'Clindamycin' (antibiotic), 'Tinidazole' (antibiotic), and 'Clotrimazole' (antifungal). Clindamycin is an antibiotic drug and works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It shows a bacteriostatic effect, which stops bacterial reproduction. Clotrimazole is an imidazole antifungal medication that prevents fungal growth by causing damage and leakage to the fungal cell membrane. Together Clindamycin+clotrimazole+tinidazole treats vaginal infections caused by bacteria, yeast, and parasites preventing white discharge, itchiness, and inflammation in the genitourinary area.
Directions for Use
Check the label for directions and use as advised by the doctor. Wash and dry the vaginal area. Lie on your back and gently insert the medicine into the vagina.
Storage
Side Effects of Clindamycin+clotrimazole+tinidazole
- Burning sensation
- Irritation
- Itching in the vaginal area
Drug Warnings
Please inform your doctor if you use any prescription, non-prescription medicines, including vitamin and herbal supplements before using Clindamycin+clotrimazole+tinidazole. Do not use Clindamycin+clotrimazole+tinidazole if you are allergic to Clindamycin+clotrimazole+tinidazole or any of its components. Let your doctor know if have any liver, kidney and gastrointestinal diseases (diarrhoea and colitis, an inflammation of the colon), allergic conditions (asthma, hay fever, eczema), diabetes, and immune system problems (HIV-AIDS). It is advised to use Clindamycin+clotrimazole+tinidazole under your doctor's supervision if you use other azole antifungal medicines. Clotrimazole and mineral oil additive in Clindamycin+clotrimazole+tinidazole may weaken rubber product's activity (such as latex condoms, diaphragms, cervical caps).
Drug Interactions
Drug-Drug Interaction: Clindamycin+clotrimazole+tinidazole may interact with anaesthetic agents/skeletal muscle relaxants (atracurium, cisatracurium, doxacurium, mivacurium, pancuronium, pipecuronium, rapacuronium, rocuronium, vecuronium, succinylcholine, tubocurarine, and metocurine) and respiratory drugs (budesonide, formoterol).
Drug-Food Interaction: No interaction found/established.
Drug-Disease Interaction: Before taking Clindamycin+clotrimazole+tinidazole, let your doctor know if have any liver, kidney, and gastrointestinal diseases (diarrhoea and colitis, an inflammation of the colon), allergic conditions (asthma, hay fever, eczema), diabetes, and immune system problems (HIV-AIDS).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
safe if prescribedNo interaction found/established.
Pregnancy
cautionThere are limited studies on how Clindamycin+clotrimazole+tinidazole affects the unborn baby during pregnancy. It is advised to use Clindamycin+clotrimazole+tinidazole after consulting your doctor.
Breast Feeding
cautionThere is limited data on how Clindamycin+clotrimazole+tinidazole affects breastfeeding infants. However, systemic absorption of Clindamycin+clotrimazole+tinidazole is negligible after topical and vaginal administration. Consult your doctor for further advice.
Driving
safe if prescribedNo interaction found/established.
Liver
cautionLet your doctor know if you have any history of liver diseases before taking Clindamycin+clotrimazole+tinidazole.
Kidney
cautionLet your doctor know if you have any history of kidney diseases before taking Clindamycin+clotrimazole+tinidazole.
Children
unsafeClindamycin+clotrimazole+tinidazole is not recommended for children below 12 years of age. Do not give this medicine to your child without medical advice.
Habit Forming
Diet & Lifestyle Advise
- Avoid frequent douching to maintain the natural moisture in the vagina.
- Use mild soap while taking baths and prefer warm baths.
- Avoid harsh products on your skin.
- Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
- Avoid or limit the intake of alcohol and caffeine.
Special Advise
- Ask your partner to use condoms during sexual intercourse, which will prevent the further spread of sexually transmitted infections like gonorrhea.
- Proper hygiene and regular cleaning/washing of the genitourinary area with anti-infective wash are advisable.
- If possible, you should wear cotton underwear and pantyhose with a cotton crotch, preventing vaginal inflammation and irritation.
- Do not take Clindamycin+clotrimazole+tinidazole during the first trimester of pregnancy.
- Do not breastfeed while you are taking Clindamycin+clotrimazole+tinidazole for at least 3 days after your last dose.
Patients Concern
Disease/Condition Glossary
Vaginal infections: It is also referred to as ‘Vaginitis’, which can cause infection or inflammation of the vagina or external part of the vagina, known as the vulva. Vaginal infections are generally caused due to bacteria, yeast, and parasites. White thick heavy discharge, foul odour, and intense itchiness around the genitourinary area are the main characteristics of vaginal infections.
Vaginal bacterial infections: It causes greyish-white or yellow discharge with a fish-like odour that can be observed after sexual intercourse.
Vaginal yeast infections: It usually produces intense itching with sometimes white viscous discharge.
Vaginal Trichomoniasis: It is a parasitic infection that produces intense vaginal itching with a foul odour. Vaginal discharge colour is usually greenish-yellow.
FAQs
Clindamycin+clotrimazole+tinidazole is used to treat vaginal infections caused by bacteria (bacterial vaginosis), yeast infection (candidiasis), and parasitic infections (trichomoniasis).
Clindamycin+clotrimazole+tinidazole is used to treat vaginal infections, such as bacterial vaginosis (BV), candidiasis and trichomoniasis. It consists of 'Clindamycin' (antibiotic), 'Tinidazole (antibiotic) and 'Clotrimazole' (antifungal). Clindamycin is an antibiotic drug and works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. Tinidazole is an antibiotic or antiprotozoal which kills amoeba and parasites. Clotrimazole is an antifungal medication that stops fungi's growth by causing damage and leakage to the fungal cell membrane.
Clindamycin+clotrimazole+tinidazole should be used with proper caution and doctor consultation if you have any liver, kidney and gastrointestinal diseases (diarrhoea and colitis, an inflammation of the colon), allergic conditions (asthma, hay fever, eczema), diabetes and immune system problems (HIV-AIDS).
Do not stop using Clindamycin+clotrimazole+tinidazole even if you feel better until the doctor's advised course is finished. Your symptoms may improve before the infection is completely cured.
Bacterial infections, yeast infections, parasitic infections, vaginal atrophy after menopause and irritants like body wash/soap/perfumes/vaginal contraceptive devices are some of the common causes of vaginal infections.
Your doctor might ask you a few questions about your sexual health, like your history of past vaginal infections or if you have had any sexually transmitted infections (STIs) like gonorrhoea. Besides this, your doctor might also perform a pelvic exam by collecting a vaginal discharge sample.
Clindamycin+clotrimazole+tinidazole usually starts working within 3 to 7 days. However, it may take several days to show its complete effects depending on the severity of your infection. Therefore, complete the course of treatment for best results.
You can urinate after using Clindamycin+clotrimazole+tinidazole as it is designed for intravaginal use, and urination does not affect its effectiveness. However, it is recommended to lie down for at least 30 minutes after insertion for optimal absorption.
You can walk after inserting Clindamycin+clotrimazole+tinidazole, but it is best to avoid physical activities immediately to ensure the medication works effectively. Therefore, for better absorption, it is advisable to lie down for at least 30 minutes and rest during this period.
Clindamycin+clotrimazole+tinidazole may cause vaginal discharge as a side effect in some individuals. To help manage this, wear breathable cotton underwear and loose-fitting clothes. Keep the vaginal area clean by gently washing with mild, fragrance-free soap and water. Avoid using scented products, douches, or harsh soaps, as these can disrupt the natural balance of bacteria and irritate the area. If you experience persistent, severe, or unusual discharge, consult your doctor for further guidance and proper evaluation.
Taking a few precautions when using Clindamycin+clotrimazole+tinidazole is essential to ensure effective treatment and minimize potential side effects. Begin by washing and drying the vaginal area before application. Avoid vaginal intercourse during the treatment period, as this can reduce the effectiveness of the medication and increase the risk of reinfection. Additionally, refrain from using tampons, douches, or other vaginal products, which can disrupt the natural balance of bacteria. Wearing loose, breathable clothing can also help keep the area dry and promote healing. Before starting treatment, inform your doctor about any allergies, medications, or underlying medical conditions. If you're pregnant or breastfeeding, consult your doctor before using Clindamycin+clotrimazole+tinidazole to discuss potential risks and benefits.
Clindamycin+clotrimazole+tinidazole may cause vomiting in some individuals. Taking the medication with a small meal or snack may help alleviate this side effect if vomiting occurs. However, if the vomiting persists, please consult your doctor for further guidance.
Clindamycin+clotrimazole+tinidazole is not recommended during pregnancy, especially in the first trimester, due to potential fetal risks. Consult your doctor for alternative treatments if you are pregnant or planning to become pregnant.
Clindamycin+clotrimazole+tinidazole may cause headaches in some individuals. If you experience a headache while taking this medication, try coping with it by resting in a quiet, dark room, staying hydrated by drinking plenty of water, and avoiding triggers like stress or certain foods. If your headache persists or worsens, consult your doctor for advice on managing this side effect.
