Dapagliflozin+sitagliptin+metformin
About Dapagliflozin+sitagliptin+metformin
Dapagliflozin+sitagliptin+metformin is an antidiabetic medicine used to treat Type II Diabetes. In type 2 diabetes, the pancreas does not produce enough insulin, or the body is unable to use insulin effectively. As a result, blood sugar levels become elevated.
Dapagliflozin+sitagliptin+metformin contains Dapagliflozin, Sitagliptin, and Metformin. It works by removing excess sugar from the body through urine, increasing the levels of certain natural substances that lower blood sugar when it is high, reducing sugar production by cells in the liver, and delaying sugar absorption from the intestines.
Take Dapagliflozin+sitagliptin+metformin as advised by your doctor. Dapagliflozin+sitagliptin+metformin may cause certain side effects such as vomiting, nausea, abdominal pain, headache and stomach upset. Most of these side effects do not need medical attention and resolve over time. If these side effects persist or worsen, please consult your doctor.
Do not take Dapagliflozin+sitagliptin+metformin if you are allergic to any of its components. Inform your doctor about your medical history and the medicines you are taking, including herbs and supplements, before starting the treatment with Dapagliflozin+sitagliptin+metformin. Let your doctor know if you are pregnant or breastfeeding before taking Dapagliflozin+sitagliptin+metformin. It is not recommended for use in children below 18 years of age.
Uses of Dapagliflozin+sitagliptin+metformin
Medicinal Benefits
- Dapagliflozin+sitagliptin+metformin is a combination of three antidiabetic medicines: Sitagliptin, Dapagliflozin, and Metformin, used in the management of Type 2 Diabetes Mellitus, along with proper diet and exercise.
- Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps increase insulin release and decrease glucagon levels in the body, lowering blood sugar levels when they are high.
- Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, works by removing excess glucose through the urine, thereby lowering blood sugar levels.
- Metformin is a biguanide which reduces the amount of sugar produced by the liver and delays glucose absorption from the intestine.
- It improves the body’s sensitivity to insulin, promoting better glucose uptake by muscles and tissues.
- The combined effect of these three drugs offers multi-targeted control of blood sugar levels, especially in patients not controlled by single or dual therapy.
- Dapagliflozin+sitagliptin+metformin helps manage blood glucose levels and prevents diabetes-related complications, such as eye problems, nerve problems, and kidney impairment.
Directions for Use
- Take Dapagliflozin+sitagliptin+metformin with food to reduce stomach upset or gastrointestinal side effects.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
- Swallow the medicine as a whole with a glass of water.
- Do not crush, break, or chew it.
Storage
Side Effects of Dapagliflozin+sitagliptin+metformin
- Headache
- Nausea
- Stomach upset
- Vomiting
- Abdominal pain
Drug Warnings
- Dapagliflozin+sitagliptin+metformin should be avoided if you are allergic to any of the components in it.
- Before starting treatment, inform your doctor about your medical history and the medications you are taking, including any herbs and supplements. This can help prevent unwanted effects.
- Dapagliflozin+sitagliptin+metformin is not recommended for use in patients with severe liver or kidney disease.
- Consult your doctor if you are pregnant or breastfeeding.
- It is not recommended for use in children below 18 years of age.
- Avoid drinking alcohol while on Dapagliflozin+sitagliptin+metformin as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
Drug Interactions
Drug-Drug Interactions: Dapagliflozin+sitagliptin+metformin interacts with an antidepressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-epileptic drugs (topiramate, lamotrigine), and heart-related chest medicine (ranolazine).
Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid the intake of alcoholic beverages with Dapagliflozin+sitagliptin+metformin.
Drug-Disease Interactions: Inform your doctor if you have any kidney or liver disease or heart problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Dapagliflozin+sitagliptin+metformin.
Pregnancy
consult your doctorThere are no adequate studies on the effect of Dapagliflozin+sitagliptin+metformin in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Dapagliflozin+sitagliptin+metformin.
Breast Feeding
cautionDapagliflozin+sitagliptin+metformin is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Dapagliflozin+sitagliptin+metformin.
Driving
safeDapagliflozin+sitagliptin+metformin usually does not affect your ability to drive or operate machinery.
Liver
cautionUse Dapagliflozin+sitagliptin+metformin with caution, as lactic acidosis can occur due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
cautionRenal impairment also increases the risk of lactic acidosis. Hence, Dapagliflozin+sitagliptin+metformin should be used with caution if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
unsafeDapagliflozin+sitagliptin+metformin is not recommended for children below 18 years as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Try doing 30 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
- Include whole-grain foods, fruits and veggies, and other fibre-enriched foods.
- Add omega-3 fatty acid-containing oils for daily cooking.
- Avoid too much stress, as it may elevate your blood sugar level. To control stress-related blood sugar changes, you can adopt stress management techniques like mindfulness, meditation, or yoga.
- Weight loss gradually to achieve a healthy body mass index (18.5 to 24.9).
- Keep your blood pressure as normal (140/90) as possible, as it reduces the risk of cardiovascular diseases in diabetes patients.
- Avoid smoking and alcohol consumption while on treatment with Dapagliflozin+sitagliptin+metformin.
- Take short, frequent meals, and avoid prolonged fasting when taking Dapagliflozin+sitagliptin+metformin.
Special Advise
- Dapagliflozin+sitagliptin+metformin may sometimes cause hypoglycemia (low blood sugar levels) as a side effect. Try to carry candies or sugar biscuits in your pocket every time you feel symptoms such as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc.
- Lifestyle modifications are the most important step in controlling blood sugar levels.
- Your doctor may advise frequent blood tests to check your blood sugar levels.
Patients Concern
Disease/Condition Glossary
Type II Diabetes Mellitus: It is a chronic and lifelong condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels. Therefore, people affected with type 2 diabetes either do not produce enough insulin or there is resistance to the action of insulin. Individuals who are middle-aged or older are most likely to suffer from type 2 diabetes, which is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, weight gain, and blurred vision.
FAQs
Dapagliflozin+sitagliptin+metformin is used to treat type II diabetes mellitus, a condition wherein the body doesn't use insulin effectively, which causes unusual blood glucose levels.
Dapagliflozin+sitagliptin+metformin is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin helps remove excess sugar from the body via urine. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines.
If you forget to take Dapagliflozin+sitagliptin+metformin, take it as soon as you remember. However, if it's time for the next dose, avoid taking it and do not double-dose to make up the missed dose. Taking an overdose might cause your sugar level to fall rapidly.
Dapagliflozin+sitagliptin+metformin may cause certain side effects such as vomiting, nausea, abdominal pain, headache and allergic reactions. If these side effects persist or worsen, please consult your doctor.
