Dexamethasone
About Dexamethasone
Dexamethasone is used to replace Dexamethasone deficiency. It treats various medical conditions, including severe allergic conditions, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, oedema, eye disorders, neoplastic states and endocrine disorders. It is also used in preoperative and postoperative support. Furthermore, it is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.
Dexamethasone contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions, such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.
Dexamethasone will be administered by a healthcare professional; do not self-administer. Some people may experience mood changes in personality, mental health problems, muscle weakness, increased appetite, irregular or absent menstrual periods, infections and infestations, impaired vision, difficulty falling asleep or staying asleep, heartburn, peptic ulcer, muscle weakness, nausea and injection site pain or redness as side effects of Dexamethasone. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Let your doctor know before prescribing Dexamethasone if you are allergic to any content of this medicine or sulphites. Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine. Before obtaining the Dexamethasone, notify your doctor about your medical history and any other medications you are currently taking to rule out any potentially harmful effects.
Uses of Dexamethasone
• Anti-Inflammatory Treatment: Dexamethasone is often used to reduce inflammation in conditions such as arthritis, allergic reactions, and other inflammatory disorders.
• Management of Allergic Reactions: Dexamethasone can be administered to alleviate severe allergic reactions or anaphylaxis by quickly reducing swelling and other symptoms.
• Cancer Treatment Support: Alongside other medications, Dexamethasone is utilized to help reduce symptoms associated with certain types of cancers, including nausea and inflammation caused by chemotherapy.
• Adrenal Insufficiency: Dexamethasone is used to replace the cortisol hormone in individuals with adrenal insufficiency, helping to regulate metabolism and manage stress responses.
• Treatment of Autoimmune Diseases: Dexamethasone is often prescribed to manage autoimmune conditions like lupus or multiple sclerosis by dampening the immune response and reducing symptoms.
Medicinal Benefits
Dexamethasone is a steroid (corticosteroids) medication. Corticosteroids occur naturally in the body and contribute to overall health and well-being. Increasing your body's corticosteroid levels (such as dexamethasone) is an effective strategy for treating various disorders involving inflammation. Dexamethasone decreases inflammation, otherwise which might worsen your disease. You must take it daily to get the maximum benefits of Dexamethasone.
Directions for Use
• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use. • Dexamethasone will be administered by the doctor or healthcare professional. • Do not self-administer.
Storage
Side Effects of Dexamethasone
- Difficulty falling asleep or staying asleep
- Mood changes in personality
- Depression
- Muscle weakness
- Increased sweating
- Increased appetite
- Weight gain
- Joint pain
- Irregular or absent menstrual periods
- Injection site pain or redness
- Mental health problems
- Infections and infestations
- Abnormal growth of tissue
- Abnormal increase in the number of white blood cells
- Abnormal hair growth
- Impaired vision
- Vertigo (spinning sensation)
- Headache
- Cataracts or feeling increased pressure in the eye
- Thickening of the heart muscle
- High blood pressure
- Blood clots in the veins
- Nausea
- Hiccups (sudden inspiration or intake of air)
- Heartburn
- Peptic ulcer
- Muscle weakness
- Loss of muscle mass
- Osteoporosis (loss of bone density)
Drug Warnings
Before prescribing Dexamethasone, inform your doctor if you are allergic to any content of this medicine or other steroid medicines. You should disclose to your doctor if you have received any live virus vaccines. You should discuss with your doctor if you have fungal infections, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, TB, bacteraemia (viable bacteria in the bloodstream), joint, liver, kidney, or heart conditions and septic arthritis resulting from gonorrhoea or tuberculosis. If you are pregnant, planning for pregnancy or breastfeeding, inform your doctor before receiving this medicine. Contact your doctor immediately if you notice mood changes or have depression and strange thoughts while Dexamethasone therapy.
Drug Interactions
Drug-Drug Interactions: Dexamethasone may interact with nonsteroidal anti-inflammatory drugs (e.g. aspirin), anticonvulsants (e.g. phenytoin), sedative-hypnotic medications (e.g. phenobarbital, primidone), antibiotics (e.g. rifampicin, rifabutin), anticancer (e.g. aminoglutethimide), anticoagulant (e.g. warfarin), antiretroviral drugs (e.g. ritonavir, darunavir), and medicines used to treat epilepsy, pain and manic depression (e.g. carbamazepine).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: If you ever had fungal infections, epilepsy, schizophrenia, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, diabetes, TB, bacteraemia (viable bacteria in the bloodstream), joint, liver, kidney, or heart conditions and septic arthritis resulting from gonorrhoea or tuberculosis or have or had a recent vaccination inform your doctor before taking Dexamethasone.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is unknown whether alcohol interacts with Dexamethasone. Please consult your doctor.
Pregnancy
cautionIf you are pregnant, inform your doctor. Your doctor will then decide if the Dexamethasone is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.
Breast Feeding
cautionInform your doctor if you are a nursing mother. The doctor will then decide if the injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.
Driving
cautionDexamethasone may cause a reduction in mental awareness; thus, avoid operating machinery or driving.
Liver
cautionInform your doctor before receiving the Dexamethasone if you have a history of or ongoing liver disease. Your doctor will adjust the dose of this medicine if required based on your condition.
Kidney
cautionInform your doctor before receiving the Dexamethasone if you have a history of or ongoing kidney disease. Your doctor may carry out extra checks while you are taking this medicine.
Children
cautionDexamethasone may affect children's growth. Therefore, your doctor may check the child's growth regularly while using the Dexamethasone.
Habit Forming
Diet & Lifestyle Advise
Diet & Lifestyle for Allergic or Inflammatory Conditions:
- Consume antioxidant-rich food. Blueberries, tomatoes, cherries, squash, and bell peppers are highly antioxidant.
- Consuming probiotic-rich foods aids in the development of the immune system's resistance to allergies.
- Consume foods rich in quercetin (a flavonoid), such as apples, cherries, spinach, broccoli, and blueberries.
- Include seasonal fruits, vegetables, whole grains, healthy fats, and fish in your daily diet.
- Limit your intake of foods that may cause allergies, such as dairy products, soy, eggs, and nuts.
- Limit the consumption of foods high in sugar that may aggravate inflammation.
- Reducing stress and having a regular sleep schedule might be beneficial.
- Avoid processed meats, refined carbohydrates, sugar, trans fats, and alcohol, as they may aggravate inflammation.
Diet & Lifestyle for Covid-19:
- Remember to always wear a mask when you're around other people. Masks help prevent illness from spreading.
- Take care of your mental health. Fear and anxiety can hamper the immune system as well. Therapy, yoga, and meditation effectively allow the mind a state of peace.
- Keep a social distance and avoid social gatherings.
- Please do not touch your eyes, nose or mouth if your hands are not clean.
- Hands should be washed with soap and water or an alcohol-based sanitiser on a regular basis.
- All surfaces should be cleaned and disinfected on a regular basis.
- Gargling with salt water and inhaling steam would be beneficial.
- Never exchange personal objects that have been contaminated with bodily fluids or blood, such as razor blades or toothbrushes.
- Never share used needles and other injection or medical devices, as they may spread viruses.
- Consume a well-balanced diet. To enhance your immune system, consume vitamin—and nutrient-rich foods like dark green, yellow, orange, and red vegetables and fruits. Choose lean protein and whole carbohydrates over processed foods.
- Consume no raw meat or eggs. Consume boiled and cooked meat, poultry, or seafood.
- If you have nausea or vomiting, eat bland, low-fat foods and avoid spicy or greasy foods.
- Spending time with family or doing whatever makes you happy might help you minimise emotional and physical stress.
Special Advise
- Dexamethasone may affect various laboratory tests. Therefore, if you are undergoing any tests, inform your doctor or lab technician that you are on treatment with Dexamethasone.
Patients Concern
Disease/Condition Glossary
Allergy: Allergy is a condition that occurs when the immune system reacts to a foreign substance that is typically not harmful to your body. These foreign substances are known as 'allergens.' Allergic condition varies from person to person. Some might be allergic to certain foods, medications, and seasonal allergies like hay fever, pollen, or pet dander. The symptoms of an allergic reaction include itching, rash, scratchy throat, itchy or watery eyes, hives or itchy red spots on the skin, or allergic rhinitis (which causes sneezing or nasal congestion).
Inflammation: It is a response generated by damage to living tissues. This response is a defence mechanism to protect the body from injury, infection, or disease. The symptoms of inflammation include redness, pain, swelling, heat, or loss of function. Inflammation can be caused by certain medications, acute and chronic conditions, exposure to foreign materials or irritants your body can't eliminate easily.
Coronavirus disease (COVID-19): Covid-19 is an infectious disease caused by the SARS-CoV-2 virus. Most persons who become ill with Covid-19 will have mild to moderate symptoms and recover without specific therapy. Some, though, will become extremely unwell and require medical assistance. The virus can spread from an infected person's mouth or nose in microscopic liquid particles when they cough, sneeze, speak, sing, or breathe. Fever, cough, tiredness, and loss of taste or smell are the most common side effects of Covid-19.
FAQs
Dexamethasone is used in conditions like severe allergy, collagen, pulmonary, blood, rheumatic, skin, gastrointestinal, oedema, eye, neoplastic, and endocrine disorders.
Dexamethasone contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your tissues.
If you are about to be vaccinated, especially if it is a live vaccine, inform your doctor that you are taking Dexamethasone because it is not recommended to take Dexamethasone and get immunised simultaneously.
Dexamethasone is not recommended for use in fungal infections. If you have any concerns, please discuss them with your doctor.
Dexamethasone may increase the risk of Infections and infestations. Therefore, it is advised that people with chickenpox (herpes simplex), shingles (herpes zoster), or measles avoid contact.
Dexamethasone is approved for treating coronavirus disease 2019 (COVID-19) in adults and adolescents (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.
Caution is advised if you are taking anticoagulants while on Dexamethasone treatment. Checking your blood clotting time is recommended to lessen the risk of bleeding.
Dexamethasone should not be used in patients with systemic fungal infections, allergies to dexamethasone or any other medicine ingredients, or patients who have recently received live vaccines.
Dexamethasone may cause side effects such as depression, muscle weakness, increased sweating, increased appetite, weight gain, joint pain, irregular menstrual periods, mental health problems, impaired vision, headache, nausea, high blood pressure, heartburns, peptic ulcers, and blood clots in veins. If these side effects persist or worsen, please consult your doctor.
Dexamethasone may interact with other medicines such as phenytoin (anticonvulsants), aspirin (nonsteroidal anti-inflammatory drugs), rifampicin (antibiotic), warfarin (anticoagulant), ritonavir (antiretroviral drugs), and aminoglutethimide (anticancer). Therefore, consult your doctor before taking other medicines while on treatment with Dexamethasone.
Store Dexamethasone at room temperature. Protect from light. Keep it out of reach of children.
It is essential to regularly monitor your blood sugar levels, electrolytes, blood pressure, and bone density if you are using Dexamethasone for long-term. Discuss with doctor for any further information.