Disodium Edta+polymyxin B Sulphate
About Disodium Edta+polymyxin B Sulphate
Disodium Edta+polymyxin B Sulphate belongs to the group of medications called 'antimicrobials,' used to treat drug-resistant infections caused by Gram-negative bacteria. It is indicated for the treatment of urinary tract infections, meningitis (inflammation of the membranes covering the spinal cord and brain), and bacteraemia (bloodstream infections) caused by certain types of bacteria, such as Staphylococcus aureus and Pseudomonas aeruginosa. A bacterial infection is a condition in which harmful bacteria grow in the body and cause illness.
Disodium Edta+polymyxin B Sulphate contains two ingredients: Polymyxin B Sulphate (an antibiotic) and Disodium EDTA (a chelating agent). Polymyxin B Sulphate works by destroying the bacterial cell membrane, a protective covering necessary for their survival, thereby killing the infection-causing bacteria. Disodium EDTA (ethylenediaminetetraacetic acid) works by reducing bacterial resistance and enhancing the effectiveness of the Polymyxin B Sulphate against the bacteria. Thus, Disodium Edta+polymyxin B Sulphate helps treat bacterial infections.
Disodium Edta+polymyxin B Sulphate will be administered by a healthcare professional in a medical setting. In some cases, Disodium Edta+polymyxin B Sulphate may cause common side effects such as diarrhoea, drowsiness, dizziness, facial flushing (redness or warmth of the face), fever, skin rash, pain, and swelling at the injection site. Most of these side effects of Disodium Edta+polymyxin B Sulphate do not require medical attention and will gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Before starting treatment with Disodium Edta+polymyxin B Sulphate, inform your doctor if you are allergic to any of its ingredients. Complete the prescribed course to prevent the infection from returning. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before receiving Disodium Edta+polymyxin B Sulphate. Keep your doctor informed about your health conditions and medication history, including prescription/non-prescription medications, vitamins, or herbal supplements, to help prevent potential side effects or interactions.
Uses of Disodium Edta+polymyxin B Sulphate
• Treatment for Bacterial Infection: Disodium Edta+polymyxin B Sulphate is frequently used for critically ill hospital patients to treat serious bacterial infections, such as meningitis, bacteremia, and urinary tract infections, especially those brought on by drug-resistant gram-negative bacteria.
Medicinal Benefits
Disodium Edta+polymyxin B Sulphate is an antimicrobial medication used to treat drug-resistant infections caused by Gram-negative bacteria. It contains two ingredients: Polymyxin B Sulphate and Disodium EDTA (a chelating agent). Polymyxin B Sulphate is an antibiotic that kills infection-causing bacteria. Disodium EDTA is a chelating agent that reduces bacterial resistance and enhances the effectiveness of Polymyxin B Sulphate against the bacteria. Thus, Disodium Edta+polymyxin B Sulphate helps treat various bacterial infections, including urinary tract infections, meningitis, and bacteraemia caused by Staphylococcus aureus and Pseudomonas aeruginosa.
Directions for Use
Storage
Side Effects of Disodium Edta+polymyxin B Sulphate
- Diarrhoea
- Drowsiness
- Dizziness
- Facial flushing (redness or warmth of the face)
- Fever
- Skin rash
- Pain and swelling at the injection site
Drug Warnings
Do not receive Disodium Edta+polymyxin B Sulphate if you are allergic to any of its ingredients. Receiving Disodium Edta+polymyxin B Sulphate without a clear sign of a bacterial infection may not be effective and can increase the risk of developing drug-resistant bacteria. Complete the full prescribed course to prevent the infection from returning. Disodium Edta+polymyxin B Sulphate should not be used to treat viral or fungal infections. Consult your doctor before receiving Disodium Edta+polymyxin B Sulphate if you are pregnant or breastfeeding. Disodium Edta+polymyxin B Sulphate may cause dizziness, so avoid standing up too quickly from a seated or lying position. Seek medical attention if you experience kidney problems (such as being unable to pass urine or changes in urine output), nerve problems (such as weakness, numbness, or tingling in the arms or legs), or Clostridium difficile-associated diarrhoea (CDAD) after receiving the medication.
Drug Interactions
Drug-Drug Interactions: Disodium Edta+polymyxin B Sulphate may interact with curariform muscle relaxants (medications used to block nerve signals to muscles) and other neurotoxic medications (tubocurarine, decamethonium, succinylcholine, gallamine, sodium citrate).
Drug-Food Interactions: No interactions have been found/established.
Drug-Disease Interactions: Inform your doctor if you experience diarrhoea, kidney problems, or nerve problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is unknown if alcohol interacts with Disodium Edta+polymyxin B Sulphate. Please consult your doctor if you have concerns regarding this.
Pregnancy
cautionIf you are pregnant or planning to become pregnant, inform your doctor before receiving Disodium Edta+polymyxin B Sulphate. Your doctor will prescribe Disodium Edta+polymyxin B Sulphate if only the benefits outweigh the risks.
Breast Feeding
cautionIf you are breastfeeding, inform your doctor before receiving Disodium Edta+polymyxin B Sulphate. Your doctor will prescribe Disodium Edta+polymyxin B Sulphate if only the benefits outweigh the risks.
Driving
consult your doctorIt is unknown if Disodium Edta+polymyxin B Sulphate affects your ability to drive. Drive only if you are mentally alert.
Liver
consult your doctorIf you have a history of liver problems, consult your doctor before receiving Disodium Edta+polymyxin B Sulphate.
Kidney
cautionIf you have a history of kidney problems, inform your doctor before receiving Disodium Edta+polymyxin B Sulphate.
Children
safe if prescribedDisodium Edta+polymyxin B Sulphate may be safe for use in children if prescribed by the doctor.
Habit Forming
Diet & Lifestyle Advise
- Include whole grains, vegetables, and fruits in your diet.
- Take probiotics after antibiotic treatment, and eat high-fibre and probiotic foods to help reduce side effects and support digestion.
- Exercise regularly to improve overall health.
- Rest well and get plenty of sleep.
- Avoid smoking and excessive alcohol consumption.
- Practice meditation and yoga to help lower stress.
- Avoid processed, fried, and spicy food.
Special Advise
- Kidney function should be assessed before starting treatment with Disodium Edta+polymyxin B Sulphate. Both blood drug levels and kidney function should be regularly monitored during the treatment.
Patients Concern
Disease/Condition Glossary
Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. These infectious or harmful bacteria produce toxins that can damage tissue and make you sick. They can target any body part and multiply very quickly. General symptoms of a bacterial infection include fever, chills, and fatigue. Anyone can become infected with a bacterial infection; however, people with a weakened immune system or those taking immunosuppressant medications are more prone to bacterial infections.
FAQs
Disodium Edta+polymyxin B Sulphate is an antimicrobial medication used to treat drug-resistant infections caused by Gram-negative bacteria. It is indicated for the treatment of urinary tract infections, meningitis (inflammation of the membranes covering the spinal cord and brain), and bacteraemia (bloodstream infections) caused by certain types of bacteria, such as Staphylococcus aureus and Pseudomonas aeruginosa.
Disodium Edta+polymyxin B Sulphate contains two ingredients: Polymyxin B Sulphate (an antibiotic) and Disodium EDTA (a chelating agent). Polymyxin B Sulphate works by destroying the bacterial cell membrane, a protective covering necessary for their survival, thereby killing the infection-causing bacteria. Disodium EDTA (ethylenediaminetetraacetic acid) works by reducing bacterial resistance and enhancing the effectiveness of the Polymyxin B Sulphate against the bacteria. Thus, Disodium Edta+polymyxin B Sulphate helps treat bacterial infections.
The common side effects of Disodium Edta+polymyxin B Sulphate may include diarrhoea, drowsiness, dizziness, facial flushing (redness or warmth of the face), fever, skin rash, pain, and swelling at the injection site. Most of these side effects of Disodium Edta+polymyxin B Sulphate do not require medical attention and will gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Diarrhoea may be a side effect of Disodium Edta+polymyxin B Sulphate. Symptoms can appear even two months after stopping Disodium Edta+polymyxin B Sulphate, so it is important to keep your doctor informed about your health condition. If diarrhoea persists or worsens, discontinue the treatment and consult your doctor. Drink enough fluids, take nutrient supplements, and avoid spicy food if you experience diarrhoea.
Disodium Edta+polymyxin B Sulphate may cause nerve problems. Consult your doctor if you experience weakness, irritability, change in balance, drowsiness, blurred vision, trouble breathing, or numbness or tingling sensation in the arms and legs.
Inform your doctor if you do not feel better even after finishing the full prescribed course of treatment. If symptoms worsen while using this medicine, consult your doctor right away.
Usually, Disodium Edta+polymyxin B Sulphate starts working soon after taking it. However, it may take a few days to kill all the harmful bacteria and make you feel better.
Please consult your doctor before receiving Disodium Edta+polymyxin B Sulphate if you are pregnant or planning to become pregnant. Your doctor will prescribe Disodium Edta+polymyxin B Sulphate if only the benefits outweigh the risks.
