Domperidone+rabeprazole
About Domperidone+rabeprazole
Domperidone+rabeprazole belongs to the class of drugs known as Proton pump inhibitors, which reduce the amount of acid your stomach produces. It treats gastroesophageal reflux disease (GERD), stomach ulcers, Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour), duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.
Domperidone+rabeprazole helps reduce stomach acid by blocking the action of an enzyme (H+/K+ ATPase, also known as the gastric proton pump), thus preventing the release of stomach acid and relieving symptoms of food pipe lining inflammation (esophagitis), gastroesophageal reflux disease (GERD), or heartburn.
Not everyone who is taking Domperidone+rabeprazole will get these side effects. Domperidone+rabeprazole may have common side effects, such as headache, diarrhoea, nausea, abdominal pain, vomiting, dizziness, and joint pain. These side effects are temporary and may resolve on their own over time. However, if these side effects persist, don't hesitate to contact your doctor.
Take Domperidone+rabeprazole as advised. Your physician will decide the dosage based on your medical condition. You should take Domperidone+rabeprazole 30 minutes before food. It is recommended not to exceed the recommended dose of Domperidone+rabeprazole. Do not chew, crush, or break the medicine.
Inform your physician if you are allergic to Domperidone+rabeprazole. Tell your doctor if you have stomach or intestinal cancer, liver problems, are allergic to Domperidone+rabeprazole or will have an endoscopy in the future. Prolonged intake of Domperidone+rabeprazole may cause a deficiency of Vitamin B12 and low levels of calcium, magnesium and Vitamin D, leading to osteoporosis. Domperidone+rabeprazole is not recommended for children below 5 years of age. Consult the doctor if you are pregnant or breastfeeding.
Uses of Domperidone+rabeprazole
• Support Digestive Health: Domperidone+rabeprazole help alleviate digestive discomfort, promoting a balanced and regular digestive system.
• Reduce Gastrointestinal Disorders: Domperidone+rabeprazole provides relief from various gastrointestinal issues, such as gas, bloating, and irregular bowel movements.
• Relieve Indigestion: Domperidone+rabeprazole offers quick relief from indigestion and related symptoms, soothing the stomach and enhancing overall comfort.
Medicinal Benefits
- Domperidone+rabeprazole is effective in healing erosive esophagitis (inflammation of the food pipe), heartburn, Zollinger-Ellison syndrome, duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.
- Domperidone+rabeprazole works by irreversibly blocking the proton pump gate, which secretes stomach acid. It can be prescribed to all age groups, including special populations like the elderly, pregnant, lactating mothers, and patients with kidney and liver disease.
- Domperidone+rabeprazole helps manage acidity-related conditions, promotes digestion, and provides relief from associated discomfort.
Directions for Use
• Take Domperidone+rabeprazole one hour before a meal or as advised by your doctor. • Follow your doctor's instructions on the dosage and timing of this medication. • Swallow Domperidone+rabeprazole as a whole with a glass of water. • Do not crush, chew or break it.
Storage
Side Effects of Domperidone+rabeprazole
- Headache
- Diarrhoea
- Nausea
- Abdominal pain
- Vomiting
- Flatulence
- Dizziness
- Joint pain
Drug Warnings
- Avoid taking Domperidone+rabeprazole if you are allergic to Domperidone+rabeprazole or have any history of gastric cancer, liver disease, low magnesium levels, or low vitamin B1.
- Prolonged intake of Domperidone+rabeprazole may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), vitamin B12, and magnesium deficiency.
- Domperidone+rabeprazole may interact with blood thinners, antifungals, anti-HIV drugs, iron supplements, and anti-cancer medications. Please inform your doctor if you are taking any of these medications.
- Intake of Domperidone+rabeprazole may mask the symptoms of gastric cancer, so if you have any severe stomach pain or blood in stool, immediately consult the doctor.
- It is advised to stop consuming alcohol and smoking, as it can cause serious side effects. This medicine is not recommended for use in children below 16 years of age.
- Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).
- Although Domperidone+rabeprazole is safe for use during pregnancy or breastfeeding, inform your doctor if you are pregnant or breastfeeding before starting treatment with Domperidone+rabeprazole. Let your doctor know if you are taking any other medicines, including supplements and herbal products, to prevent any interactions.
- Store Domperidone+rabeprazole at room temperature. Keep the medicine out of reach of children. Do not take more than the recommended dose of medicine, as it can cause undesirable effects.
- It is always important to check the expiry date of the medicine. Discard the medicine if it reaches the expiry date.
Drug Interactions
Drug-Drug Interactions: Domperidone+rabeprazole may interact with a blood thinner (clopidogrel, warfarin), antifungal (ketoconazole, voriconazole, itraconazole, fluconazole, posaconazole), anti-HIV drug (atazanavir, amprenavir, nelfinavir), antacid (magnesium hydroxide, aluminium hydroxide, cimetidine), iron supplements, antibiotics (clarithromycin, erythromycin, ampicillin, rifampicin), heart medicine (atropine, digoxin, amiodarone), blood pressure-lowering medicines (diltiazem), anti-cancer drug (methotrexate) and anti-nausea pills (aprepitant).
Drug-Food Interactions: Domperidone+rabeprazole interacts with St John's wort plant that is used as an anti-depressant. This plant may affect the working of Domperidone+rabeprazole. So avoid its intake with Domperidone+rabeprazole.
Drug-Disease Interactions: Domperidone+rabeprazole should not be given in patients with C. difficile-induced colitis, liver disease, bone fractures, low Vitamin B12 (anaemia), and low magnesium (hypomagnesemia).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeDrinking alcohol with Domperidone+rabeprazole may cause dehydration and elevate the level of stomach acid, thereby decreasing its efficiency. So try to avoid, limit alcohol or contact a doctor before intake of Domperidone+rabeprazole.
Pregnancy
consult your doctorIt is not known whether the Domperidone+rabeprazole affects the baby or not. So, contact a doctor before intake of Domperidone+rabeprazole. Your doctor will weigh the benefits and potential risks before prescribing them.
Breast Feeding
consult your doctorDomperidone present in Domperidone+rabeprazole passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of Domperidone+rabeprazole. Your doctor will weigh the benefits and potential risks before prescribing them.
Driving
cautionIn some cases, Domperidone+rabeprazole may cause dizziness, sleepy, or blur vision. If you observe these symptoms do not drive or operate heavy machinery until you feel better.
Liver
consult your doctorIf u have or had history or evidence of any liver-related diseases, please consult the doctor before taking medicine.
Kidney
consult your doctorIf u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.
Children
unsafeDomperidone+rabeprazole is not recommended for use in children due to a lack of data on safety and efficacy. Please consult your doctor.
Habit Forming
Diet & Lifestyle Advise
- Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
- Avoid taking alcohol and smoking cigarette. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
- Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.
- Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
- Include high fibre containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine.
- Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production. Cranberry juice can be beneficial in the peptic ulcer and H Pylori infection.
Special Advise
Do not take Domperidone+rabeprazole for more than four weeks of duration without consulting the doctor.
Patients Concern
Disease/Condition Glossary
Acidity: Normally, a thick layer of mucus protects the stomach against its own acid secretion. But, in the long run, it gets eroded by excessive stomach acid production, leading to complications like GERD, peptic ulcer, and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn.
Peptic ulcers: It is a condition in which sores or ulcers develop in the stomach lining or duodenum (the first part of the small intestine).
Zollinger-Ellison syndrome: It is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production, leading to peptic ulcers.
FAQs
Domperidone+rabeprazole is used to treat Gastro-Esophagal Reflux Disease (GERD), acid reflux, heartburn, peptic ulcer, stomach ulcers, and dyspepsia (stomach discomfort due to indigestion). It works by blocking the actions of the gastric proton pump, increasing the motility of the upper gastrointestinal tract and blocking the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).
No. Domperidone+rabeprazole prevents excess production of stomach acid causing acid reflux and heartburn. If blood is coming in your stool or mucous immediately contact the doctor.
Yes, Domperidone+rabeprazole can cause dry mouth and it is due to domperidone. In case you fell excessive thirsty, please increase your fluid intake and do frequent mouth rinses.
Diarrhoea might be a side-effect of Domperidone+rabeprazole. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or any other discomfort.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Domperidone+rabeprazole is contraindicated in patients with a known hypersensitivity to domperidone or rabeprazole or any other inactive ingredients of Domperidone+rabeprazole. Domperidone+rabeprazole should be used with caution in patients with underlying liver or kidney disease.
Store Domperidone+rabeprazole at room temperature in a cool and dry place protected from light. Keep it out of reach of children.
Yes, Domperidone+rabeprazole is safe for most of the patients. However, in some patients it may cause common side effects such as stomach pain, diarrhea, flatulence (gas), dryness in mouth, headache, dizziness, and other uncommon and rare side effects. If these side effects persist or worsen, please consult your doctor.
It is preferable to take Domperidone+rabeprazole on an empty stomach or before the first meal of the day.
Yes, Domperidone+rabeprazole may increase the risk of developing irregular heartbeat (serious arrhythmias). Although, it is a serious side effect, it is extremely unlikely to occur. Patients aged above 60 years are at higher risk.
