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About IRBESARTAN+HYDROCHLOROTHIAZIDE

HYDROCHLOROTHIAZIDE+IRBESARTAN is an 'anti-hypertensives' medication primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. High blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it increases the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.

HYDROCHLOROTHIAZIDE+IRBESARTAN is a combination of two medicines, namely: Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. On the other hand, Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, HYDROCHLOROTHIAZIDE+IRBESARTAN lowers fluid overload, raised blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

Take HYDROCHLOROTHIAZIDE+IRBESARTAN as prescribed. Your doctor will advise you on how often you take your tablets based on your medical condition. You may experience nausea, taste change, upset stomach, diarrhoea, dizziness, headache, electrolyte imbalance, and decreased blood pressure in some cases. Most of these side effects of HYDROCHLOROTHIAZIDE+IRBESARTAN do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use potassium supplements or salt substitutes unless the doctor has told you. If you notice unexplained muscle pain, dark colour urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase heart disease and stroke risk. Inform your doctor if you are suffering from any kidney or liver or heart disease or are diabetic. Do not use HYDROCHLOROTHIAZIDE+IRBESARTAN if you cannot urinate, are dehydrated, have low blood pressure (hypotension), and have or have had cardiogenic shock (sudden stopping of blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine. Reducing table salt (sodium chloride) in your food often helps lower blood pressure. Do not take HYDROCHLOROTHIAZIDE+IRBESARTAN if you are more than 3 months pregnant, if you have diabetes or impaired kidney function; if you suffer from potassium deficiency (hypokalaemia)/sodium deficiency (hyponatraemia), gout (Pain and inflammation occur when a high amount of uric acid crystallises and deposits in the joints). Check your serum electrolytes, creatinine and urea, serum lipids (cholesterol and triglycerides), uric acid, and blood sugar levels regularly as advised by your doctor.

Uses of IRBESARTAN+HYDROCHLOROTHIAZIDE

Hypertension (high blood pressure)

Medicinal Benefits

HYDROCHLOROTHIAZIDE+IRBESARTAN is primarily used to reduce high blood pressure. It is a combination of two medicines, namely: Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. On the other hand, Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, HYDROCHLOROTHIAZIDE+IRBESARTAN lowers fluid overload, raised blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

Directions for Use

Take HYDROCHLOROTHIAZIDE+IRBESARTAN as prescribed by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of IRBESARTAN+HYDROCHLOROTHIAZIDE

  • Nausea
  • Taste change
  • Upset stomach
  • Diarrhoea
  • Dizziness
  • Headache
  • Electrolyte imbalance
  • Decreased blood pressure

In-Depth Precautions and Warning

Drug Warnings

Inform your doctor before taking HYDROCHLOROTHIAZIDE+IRBESARTAN, if you are already taking medicine that has aliskiren in it if you have diabetes or kidney problems, if you have severe liver disease, if you suffer from gout, potassium deficiency (hypokalaemia)/sodium deficiency (hyponatremia). Stop taking HYDROCHLOROTHIAZIDE+IRBESARTAN if you experience pronounced gastrointestinal troubles, blood count changes, disorders of the central nervous system, or allergic reactions.  Inform your doctor before taking HYDROCHLOROTHIAZIDE+IRBESARTAN about all your ongoing medications. Your doctor may check your blood pressure, kidney function, and the number of electrolytes in the blood at regular intervals. HYDROCHLOROTHIAZIDE+IRBESARTAN should not be given to children and adolescents under 18 years of age. Drink sufficient quantities of liquid while on this medication. If you are pregnant or breastfeeding, do not take HYDROCHLOROTHIAZIDE+IRBESARTAN as it is a category D pregnancy drug and can harm the baby.

Drug Interactions

Drug-Drug Interactions: This medicine may interact with aliskiren (medicine for high blood pressure), lithium (medicine for major depressive disorder), painkillers, Metformin (diabetes medicine), Allopurinol (medicine for jaundice), Cholestyramine (medicine for diarrhoea), Vitamin D supplements, Carbamazepine (medicine for epilepsy), and Methyldopa (medicine for hypertension).

Drug-Food Interactions: HYDROCHLOROTHIAZIDE+IRBESARTAN may interact with high potassium-containing food and drinks. So, if you are using any of the OTC items, please tell your doctor. Also, alcohol should not be consumed while taking HYDROCHLOROTHIAZIDE+IRBESARTAN.

Drug-Disease Interactions: The efficacy of HYDROCHLOROTHIAZIDE+IRBESARTAN is affected, and the disease condition may even worsen if taken in patients with a recent or history of heart attack, low blood pressure, low potassium level, low electrolytes (sodium, potassium, calcium, etc.), severe liver disease, anuria (non-passage of urine), angioedema (an allergic condition with swelling under the skin), kidney disease, asthma, diabetes.

Drug-Drug Interactions Checker List:

  • ALISKIREN
  • LITHIUM
  • METFORMIN
  • ALLOPURINOL
  • CHOLESTYRAMINE
  • VITAMIN D
  • CARBAMAZEPINE
  • METHYLDOPA

    • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      You are recommended not to consume alcohol and HYDROCHLOROTHIAZIDE+IRBESARTAN to avoid unpleasant side effects like drowsiness, dizziness, and liver damage.

    • Safety Warning

      Pregnancy

      unsafe

      HYDROCHLOROTHIAZIDE+IRBESARTAN is not recommended during pregnancy as it is a category D pregnancy drug. This medicine may cause fetal damage and can affect the unborn baby (fetus).

    • Safety Warning

      Breast Feeding

      caution

      HYDROCHLOROTHIAZIDE+IRBESARTAN is known to pass breast milk, but its effect on the baby is not known. So, before breastfeeding, let your doctor know about this.

    • Safety Warning

      Driving

      caution

      Drive with caution, HYDROCHLOROTHIAZIDE+IRBESARTAN usually causes drowsiness and affects driving ability.

    • Safety Warning

      Liver

      caution

      HYDROCHLOROTHIAZIDE+IRBESARTAN to be taken with caution, especially if you have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

    • Safety Warning

      Kidney

      caution

      HYDROCHLOROTHIAZIDE+IRBESARTAN to be taken with caution, especially if you have had a history of kidney disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

    • Safety Warning

      Children

      unsafe

      Efficacy and safety of HYDROCHLOROTHIAZIDE+IRBESARTAN have not been established in children. So, HYDROCHLOROTHIAZIDE+IRBESARTAN should not be given to children under 18 years of age.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Keep your weight under control with a BMI of 19.5-24.9.
    • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
    • Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
    • If you are taking alcohol, then only one serving for women and two servings for men is advisable.
    • Quitting smoking is the best strategy to lower the risk of heart disease.
    • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
    • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
    • Try to include heart-healthy omega-3 fatty acids containing food and drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

    Special Advise

    Do not use potassium supplements or salt substitutes while using HYDROCHLOROTHIAZIDE+IRBESARTAN unless your doctor has told you to do so.

    Patients Concern

    Disease/Condition Glossary

    Hypertension: It is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.

    FAQs

    How does HYDROCHLOROTHIAZIDE+IRBESARTAN work?

    HYDROCHLOROTHIAZIDE+IRBESARTAN is a combination of two medicines, namely: Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin and relaxes blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. Hydrochlorothiazide (diuretic or water pill), removes extra water and certain electrolytes from the body. Together, both lower fluid overload, blood pressure, improves blood flow, and reduce the future risk of a heart attack.

    Can use of HYDROCHLOROTHIAZIDE+IRBESARTAN cause dizziness?

    Yes, HYDROCHLOROTHIAZIDE+IRBESARTAN can cause dizziness. It is advised to avoid driving or operate any heavy machinery while taking HYDROCHLOROTHIAZIDE+IRBESARTAN. In case you feel dizzy or lightheaded, it is advised to rest for some time until you feel better.

    Does the intake of HYDROCHLOROTHIAZIDE+IRBESARTAN affect fertility?

    It's unlikely that HYDROCHLOROTHIAZIDE+IRBESARTAN affects fertility in men or women. However, in some cases, some water pills like hydrochlorothiazide may lead to erectile dysfunction. For the best advice, please consult your doctor.

    What should I do if I miss a dose of HYDROCHLOROTHIAZIDE+IRBESARTAN?

    In case you have missed a dose of HYDROCHLOROTHIAZIDE+IRBESARTAN, you are advised to take it as soon as you remember. However, try not to miss a dose in the first place, if it's time for you to take your next dose, then do not take both the doses together. Take only one dose; taking a double dose of HYDROCHLOROTHIAZIDE+IRBESARTAN will lead to low blood pressure.

    How long can HYDROCHLOROTHIAZIDE+IRBESARTAN be taken?

    HYDROCHLOROTHIAZIDE+IRBESARTAN can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor. Discontinuing HYDROCHLOROTHIAZIDE+IRBESARTAN may lead to increased blood pressure with a high risk of heart attack and stroke in the future.

    Can I stop taking HYDROCHLOROTHIAZIDE+IRBESARTAN when my blood pressure is under control?

    No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.

    Can I take HYDROCHLOROTHIAZIDE+IRBESARTAN before surgery?

    Please inform your doctor before surgery if you are taking HYDROCHLOROTHIAZIDE+IRBESARTAN. It needs to be stopped because it might lower the blood pressure further if taken along with certain local anaesthetic medication.

    Available Medicines for

    HYDROCHLOROTHIAZIDE+IRBESARTAN