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METHYLCOBALAMIN+PREGABALIN belongs to the class of medications ‘anticonvulsants’ used in the treatment of neuropathic pain. Neuropathic pain is a chronic (long-term) progressive nerve disease that causes nerve pain due to nerve damage or the nervous system's malfunctioning. It is mostly seen in patients who had suffered a trauma or nerve injury, diabetes, vitamin deficiencies, cancer, multiple sclerosis (disease of the brain and spinal cord), shingles (a viral infection), and HIV.

METHYLCOBALAMIN+PREGABALIN is a combination of two medicines: Pregabalin and Methylcobalamin. Pregabalin acts by decreasing the pain signals sent by a damaged nerve in the body. On the other hand, Methylcobalamin helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (outer protective layer of nerve cell - neuron).

You should take this medicine as prescribed by your doctor. The common side-effects of METHYLCOBALAMIN+PREGABALIN are dizziness, drowsiness, headache, anorexia (loss of appetite), nausea or vomiting, diarrhea, headache, hot sensation (burning pain), vision problems, and diaphoresis (sweating). Inform your doctor if any of these side effects persist.

Do not take METHYLCOBALAMIN+PREGABALIN if you are allergic to ‘Pregabalin’ and ‘Methylcobalamin’ or any contents before taking METHYLCOBALAMIN+PREGABALIN if you have a history of heart diseases, liver or kidney disease, alcoholism, or drug abuse.  It should not be used in children and adolescents below 18 years. Inform your doctor if you are pregnant and breastfeeding. Do not drive or operate heavy machinery as METHYLCOBALAMIN+PREGABALIN may cause dizziness or drowsiness. METHYLCOBALAMIN+PREGABALIN contains lactose, so inform your doctor if you have any intolerance to sugars. Do not discontinue treatment without telling your doctor. 


Neuropathic pain

Medicinal Benefits

METHYLCOBALAMIN+PREGABALIN is a combination of two drugs: Pregabalin and Methylcobalamin. Pregabalin is an anticonvulsant that affects the brain's chemicals that send pain signals across the nervous system. It works by binding to the specific site on voltage-gated calcium channels (responsible for excitatory response), thereby decreasing brain activity. This effect helps in relieving nerve pain and lowers the risk of seizures. On the other hand, Methylcobalamin is a form of vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a substance called myelin (outer protective layer of nerve cells). Together, METHYLCOBALAMIN+PREGABALIN helps in providing relief from neuropathic pain and improved nerve signal conduction.  


Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.


Store in a cool and dry place away from sunlight


  • Dizziness
  • Drowsiness
  • Headache
  • Anorexia (loss of appetite)
  • Nausea or vomiting
  • Diarrhea
  • Headache
  • Sore throat
  • Vision problems
  • Hot sensation (burning pain)
  • Diaphoresis (sweating)
  • Weight gain

In-Depth Precautions and Warning

Drug Warnings

METHYLCOBALAMIN+PREGABALIN may increase the risk of heart failure in patients with heart diseases. It may cause dizziness and somnolence (sleepiness). So, it might increase the risk of accidental injury in elderly patients. METHYLCOBALAMIN+PREGABALIN may also cause temporary vision problems. However, if this condition is persistent, consult your doctor immediately. Patients with diabetes who gain weight with METHYLCOBALAMIN+PREGABALIN may need a change in diabetic medicines. If you notice decreased urination while taking METHYLCOBALAMIN+PREGABALIN, inform your doctor as METHYLCOBALAMIN+PREGABALIN may cause kidney failure in some cases. It may increase suicidal tendencies, though it is rare. You may experience convulsions after discontinuing METHYLCOBALAMIN+PREGABALIN. In such cases, inform your doctor immediately.  

Drug Interactions

Drug-Drug Interaction: METHYLCOBALAMIN+PREGABALIN may interact with a pain killer (oxycodone), opioids, antianxiety drugs (lorazepam), antacid (omeprazole), antibiotic (neomycin), and anti-gout medication (colchicine). 

Drug-Food Interaction: Avoid alcohol consumption while using METHYLCOBALAMIN+PREGABALIN. 

Drug-Disease Interaction: METHYLCOBALAMIN+PREGABALIN should be used with caution in patients with liver diseases, kidney diseases, heart problems, alcoholism, drug abuse, and suicidal tendencies. 

Safety Advice

  • Safety Warning


    Alcohol may worsen the condition by increasing the risk of side-effects.

  • Safety Warning


    Consult Your Doctor

    METHYLCOBALAMIN+PREGABALIN is a category C medicine. It is not recommended for use in pregnant women unless the doctor thinks the benefits outweigh the risks.

  • Safety Warning

    Breast Feeding

    METHYLCOBALAMIN+PREGABALIN should be used with caution in breastfeeding mothers unless the doctor thinks the benefits outweigh the risks.

  • Safety Warning


    METHYLCOBALAMIN+PREGABALIN may cause dizziness and drowsiness. So, avoid driving or operating heavy machinery while using METHYLCOBALAMIN+PREGABALIN.

  • Safety Warning


    METHYLCOBALAMIN+PREGABALIN should be used with caution in patients with liver diseases. Dose adjustments may be necessary.

  • Safety Warning


    METHYLCOBALAMIN+PREGABALIN should be used with caution in patients with kidney diseases. Dose adjustments may be necessary

Habit Forming


Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain.
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.


Special Advise

  • METHYLCOBALAMIN+PREGABALIN may increase suicidal thoughts. Extreme caution is advised with people suffering from suicidal tendencies or psychological problems.
  • METHYLCOBALAMIN+PREGABALIN is known to cause dizziness and sleepiness, so it is advised to refrain from driving or doing any work that requires attention or concentration.

Patients Concern

Disease/Condition Glossary

Neuropathic pain: Neuropathic pain is caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease, infection, or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation. A feeling of numbness and loss of sense is also a common symptom of neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury, the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).



METHYLCOBALAMIN+PREGABALIN is a combination of two medicines: Pregabalin and Methylcobalamin. METHYLCOBALAMIN+PREGABALIN block the brain's pain signals and protect nerve cells from further damage, thereby improving nerve signal conduction to the whole body parts. These effects help to reduce pain in patients with neuropathic pain.

Can METHYLCOBALAMIN+PREGABALIN be given to children?

METHYLCOBALAMIN+PREGABALIN should not be given to children and adolescents under the age of 18 years as it may increase suicidal thoughts.

Can I stop taking METHYLCOBALAMIN+PREGABALIN if I feel better?

METHYLCOBALAMIN+PREGABALIN should not be stopped abruptly as it may cause withdrawal reactions such as trouble sleeping, headache, nausea, feeling anxious, diarrhea, flu-like symptoms, convulsions, nervousness, depression, pain, sweating, and dizziness. METHYLCOBALAMIN+PREGABALIN should be stopped gradually over a minimum of 1 week.


METHYLCOBALAMIN+PREGABALIN can be used in patients with diabetes if they have neuropathic pain. However, inform your doctor if you notice any weight gain while using METHYLCOBALAMIN+PREGABALIN. Your doctor may change your diabetic medicines to stop weight gain. Also, take some measures to control weight such as eating a balanced diet and exercising regularly.


METHYLCOBALAMIN+PREGABALIN may cause drowsiness. So, it is advised to refrain from activities such as driving or operating heavy machinery if you feel sleepy after taking METHYLCOBALAMIN+PREGABALIN.

When will my pain improve after taking METHYLCOBALAMIN+PREGABALIN?

You may notice pain improvement within 2-3 days after taking METHYLCOBALAMIN+PREGABALIN. However, it may take 2-3 months for your symptoms to improve depending on your health condition.

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