Naproxen+domperidone
About Naproxen+domperidone
Naproxen+domperidone belongs to the group of medications called analgesics. It treats migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). Migraine is a condition characterised by intense headaches. Pain is a symptom that occurs due to various underlying conditions. It also controls nausea and vomiting associated with migraine.
Naproxen+domperidone is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclooxygenase (COX) enzyme in the body, which produces certain chemical substances, such as prostaglandins, that cause pain and swelling. Domperidone is an antiemetic agent that prevents nausea and vomiting symptoms by blocking specific receptors, such as dopamine and serotonin, that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.
Take Naproxen+domperidone as prescribed by your doctor. You are advised to take Naproxen+domperidone for as long as your doctor has prescribed it for you based on your medical condition. Common side effects of Naproxen+domperidone are dry mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems, and headache. Consult your doctor if you feel any discomfort.
Before taking the Naproxen+domperidone, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. If you are pregnant or breastfeeding, please tell your doctor so that your doctor can weigh the benefits and any potential risks before prescribing it to you. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to painkillers. Patients above 65 years of age, with pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use Naproxen+domperidone only when prescribed by a doctor.
Uses of Naproxen+domperidone
• Effective Pain Relief: Naproxen+domperidone is commonly prescribed to alleviate moderate to severe pain, including headaches, dental pain, menstrual cramps, and postoperative discomfort. It works by blocking the production of chemicals responsible for inflammation and pain.
• Powerful Anti-inflammatory Action: With its active ingredient, naproxen, Naproxen+domperidone helps reduce inflammation associated with conditions like osteoarthritis and rheumatoid arthritis, providing relief from joint pain and swelling.
• Fever Management: Naproxen+domperidone is also effective in lowering fever across various conditions, offering relief and aiding the body's recovery process.
• Relief for Muscle Pain: Whether caused by exercise, strains, or injuries, Naproxen+domperidone can help alleviate muscle pain, improving comfort and mobility.
• Nausea and vomiting: It also controls nausea and vomiting associated with migraine headaches.
Medicinal Benefits
Naproxen+domperidone is a combination of naproxen and domperidone. Naproxen is an anti-inflammatory (reduces inflammation) and analgesic (reduces pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty the stomach. Easy movement of food through the stomach helps in relieving nausea and vomiting. It blocks the dopamine receptors present in the chemoreceptor trigger zone, which is responsible for regulating nausea and vomiting.
Directions for Use
- Naproxen+domperidone can be taken with meals, to avoid stomach ulcers and irritation.
- Follow your doctor's instructions on the dosage and timing of this medication.
- Swallow the whole tablet with a glass of water.
- Do not crush, chew or break it.
Storage
Side Effects of Naproxen+domperidone
- Abdominal pain
- Constipation
- Indigestion
- Flatulence
- Dry mouth
- Glossitis (inflammation of the tongue)
- Diarrhoea
- Drowsiness
- Dizziness
- Headache
- Vision problems
- Hearing problems
Drug Warnings
Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDS (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDS) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, are older in age, are an alcoholic or have multiple diseases. The risk of having a heart attack increases if you smoke, or you or your family has a history of heart failure, stroke, or hypertension. Call for medical help immediately if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.
Drug Interactions
Drug-drug interactions: Naproxen+domperidone may interact with other NSAIDs (ketorolac), anticoagulants (warfarin), corticosteroids (prednisolone), anti-hypertensive medications (ramipril and amlodipine), antibiotics (amikacin), lipid-lowering drugs (atorvastatin), and antidepressants (citalopram and fluoxetine).
Drug-food interactions: No interactions found.
Drug-disease interactions: Patients with peptic ulcers, inflammatory bowel disease (inflammation of the digestive tract), liver diseases, kidney diseases, heart problems, and respiratory diseases should take the Naproxen+domperidone only when prescribed by a doctor.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is advised not to take alcohol as Naproxen+domperidone can cause dizziness or drowsiness.
Pregnancy
cautionNaproxen+domperidone should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.
Breast Feeding
cautionNaproxen+domperidone should be used in breastfeeding mothers only if the benefits outweigh the risks.
Driving
unsafeIt is unsafe to drive after taking Naproxen+domperidone as it impacts your ability to drive or operate machinery.
Liver
cautionLimited information was available for the use of Naproxen+domperidone in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Naproxen+domperidone in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
cautionLimited information was available for the use of Naproxen+domperidone in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using Naproxen+domperidone in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.
Children
cautionNaproxen+domperidone should be used in children below 12 years of age only when prescribed by a child specialist.
Habit Forming
Diet & Lifestyle Advise
- Drink plenty of fluids to avoid gastrointestinal problems.
- Avoid triggers that can increase your migraine headache.
- Take enough rest.
- Acupuncture, massage and physical therapy may also be helpful.
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
- Avoid smoking and alcohol consumption.
- Performing yoga may also help in improving joint flexibility and pain management.
- Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
Special Advise
- Your doctor may monitor liver function and kidney function if you are taking Naproxen+domperidone for long-term.
- Taking meals at the same time every day and sufficient sleep might help in avoiding migraine attacks. You are recommended to avoid loud music, noisy place, extreme temperatures and bright light. Also, avoid consumption of chocolates, cheese, processed food, smoking and alcohol.
Patients Concern
Disease/Condition Glossary
Migraine: Migraine is a condition characterised by intense headaches. It also causes nausea, vomiting, sensitivity to light and sound and difficulty speaking. Bright lights, strong smells, certain foods, loud sounds, stress and hormonal changes act as triggers for migraine. These triggers lead to acute attacks. Acute migraine attacks result in throbbing headaches and pain in the eyes, face or neck.
Pain: Pain is a widely used term that describes unpleasant feelings or discomfort. It ranges from mild to severe. The severity of the pain depends on the underlying condition.
Rheumatoid arthritis is an autoimmune disease in which the body's immune system attacks its own tissue, leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.
Gout: Gout is an inflammatory condition in which uric acid deposits and crystallises in the joints. It is characterised by acute, severe, and recurring pain attacks, especially at night, as well as redness and swelling in the affected joints.
Dysmenorrhea: Dysmenorrhea refers to abdominal cramps/pain and an unpleasant sensory/emotional experience associated with irregular periods. It occurs just before or during menses. Menstrual cramps that cause throbbing pain in the lower belly during periods may vary from mild to severe. Some of the common symptoms of menstrual cramps include an aching pain in your abdomen (sometimes severe), a feeling of pressure in your belly, pain in your hips, lower back, and inner thighs.
FAQs
Naproxen+domperidone is used to treat migraine headaches, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). It also controls nausea and vomiting associated with migraines.
Naproxen works by inhibiting the cyclooxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins that induce pain and swelling. Domperidone is an antiemetic that blocks specific receptors, such as dopamine and serotonin receptors, that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).
Naproxen+domperidone cannot permanently cure migraine. It can provide relief from pain and headache.
Naproxen+domperidone on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be only used for a duration as prescribed by the doctor.
Arthritis is a chronic condition of joints with pain and inflammation. Naproxen+domperidone does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness.
Yes, Naproxen+domperidone may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Naproxen+domperidone.
Dry mouth may be caused by Domperidone in Naproxen+domperidone. Chew a sugar-free sweet or sugar-free gum.
Yes, Naproxen+domperidone is a painkiller. It contains Naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain and inflammation, while Domperidone helps manage nausea, which is common in migraines. Besides this, it can also be used to reduce pain in gout, rheumatoid arthritis, and dysmenorrhea (menstrual pain).
Naproxen+domperidone usually starts working within 30-60 minutes after oral intake. However, the exact time may vary based on individual response and medical condition. Always consult your doctor for personalized guidance and proper usage.
To ensure safe and effective treatment, it's helpful to know that Naproxen+domperidone may have a potential impact on blood pressure, but with proper monitoring, you can minimize risks. By working closely with your healthcare provider, you can enjoy the benefits of Naproxen+domperidone while maintaining healthy blood pressure. Open communication with your doctor is key to a successful treatment plan.
Naproxen+domperidone is a combination medication that pairs a nonsteroidal anti-inflammatory drug (NSAID) with an antiemetic and prokinetic agent. This combination helps relieve pain and prevents nausea, improving overall comfort.
The side effects of Naproxen+domperidone include dryness of the mouth, constipation, abdominal pain, drowsiness, dizziness, visual disturbances, hearing problems and headache. Most of these side effects do not require medical attention and gradually resolve over time. However, please consult your doctor if any symptoms persist or worsen.
You should consult your doctor before stopping Naproxen+domperidone, even if your migraine is relieved. It is generally used as needed for migraine attacks, but stopping suddenly without medical advice may not be ideal. Follow the dosage instructions provided by your doctor and complete the entire treatment course to treat your medical condition effectively.
Yes, Naproxen+domperidone may cause diarrhoea, a common side effect. If you experience this symptom, drink plenty of water to stay hydrated, take probiotics, avoid spicy, fatty, or dairy foods, and limit caffeine intake to manage diarrhoea.
To ensure a safe and effective treatment experience with Naproxen+domperidone, it's essential to be aware of certain contraindications. By knowing these guidelines, you can minimize risks and maximize benefits. Naproxen+domperidone is not recommended for individuals with NSAID hypersensitivity, NSAID-induced asthma, or severe allergic reactions, as well as during pregnancy, especially after 30 weeks, and in cases of severe liver impairment, heart conditions, or significant electrolyte disturbances. Additionally, caution is advised for patients with gastrointestinal bleeding, obstruction, or prolactin-releasing pituitary tumours and when taking QT-prolonging drugs or potent CYP3A4 inhibitors. By working closely with your healthcare provider, you can navigate these guidelines and enjoy a successful treatment outcome.
Yes, prolonged or frequent use of Naproxen+domperidone may cause kidney damage as it contains Naproxen, an NSAID, which can affect kidney function, especially with long-term use. Therefore, it should only be used as a doctor prescribes to minimize the risk.
No, you should not take a higher than the recommended dose of Naproxen+domperidone, as it may cause serious side effects like irregular heartbeat, drowsiness, extreme tiredness, nausea, stomach pain, and breathing difficulties. If you accidentally take more than the prescribed dose, seek immediate medical attention.
Naproxen+domperidone should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.
