Ondansetron
About Ondansetron
Ondansetron is an antiemetic used to prevent and treat nausea and vomiting during chemotherapy. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.
Ondansetron contains Ondansetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
Ondansetron will be administered by a healthcare professional. Do not self-administer. In some cases, Ondansetron may cause headache, constipation, a feeling of warmth or flushing, redness, and irritation at the site of injection. Most of these side effects of Ondansetron do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Ondansetron, Palanosetron, Granisetron, or any other medicines, please tell your doctor. Ondansetron should be given to children only in doses advised by the doctor based on the child’s body weight or body surface area. If you are pregnant or breastfeeding, you must inform your doctor before receiving Ondansetron.
Uses of Ondansetron
Medicinal Benefits
Ondansetron contains Ondansetron that blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting caused by chemotherapy in adults and children and also after surgery. Additionally, Ondansetron can be used to prevent nausea and vomiting caused by radiotherapy for cancer in adults.
Directions for Use
Storage
Side Effects of Ondansetron
- Headache
- Constipation
- A feeling of warmth or flushing
- Redness and irritation at the site of injection
Drug Warnings
If you are allergic to Ondansetron, Palanosetron, Granisetron, or any other medicines, please tell your doctor. Ondansetron should be given to children only in doses as advised by the doctor based on the child’s body weight or body surface area. Ondansetron should be used during pregnancy or breastfeeding after consultation with a doctor. If you have problems with levels of sodium, magnesium, and potassium salts in your blood, inform your doctor before taking Ondansetron.
Drug Interactions
Drug-Drug Interaction: Ondansetron may interact with anticonvulsants (phenytoin, carbamazepine), antituberculosis drug (rifampicin), antibiotics (erythromycin), antifungal (ketoconazole), narcotic analgesics (tramadol, methadone), beta-blockers, anti-arrhythmic medicines, antidepressants (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, escitalopram, duloxetine, venlafaxine), chemotherapy drugs (anthracyclines, trastuzumab) and antipsychotic (haloperidol).
Drug-Food Interaction: No interactions found.
Drug-Disease Interaction: If you have a blockage in the gut, liver or heart problems, imbalance of potassium, sodium and magnesium in the blood, inform your doctor before taking Ondansetron.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consuming alcohol while taking Ondansetron as this medicine can interact with alcohol and may worsen the side effects.
Pregnancy
safe if prescribedIf you are pregnant, inform your doctor before taking Ondansetron. Your doctor will weigh the benefits and risks before prescribing this medicine.
Breast Feeding
safe if prescribedIf you are a nursing mother, inform your doctor before taking Ondansetron. Your doctor will weigh the benefits and risks before prescribing this medicine.
Driving
safeOndansetron usually does not affect your driving ability. However, do not drive if you feel any discomfort.
Liver
cautionTake Ondansetron with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
safe if prescribedOndansetron may be safe to use in patients with kidney problems if prescribed by a doctor.
Children
cautionOndansetron should be used in children only in doses advised by the doctor based on child’s body weight or body surface area.
Habit Forming
Diet & Lifestyle Advise
Eat a healthy and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
Drink any other liquid at least 30 minutes after eating food.
If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.
Patients Concern
Disease/Condition Glossary
Nausea and vomiting: Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short, nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). A receptor located in the brain known as the chemoreceptor trigger zone (CTZ) controls vomiting.
FAQs
Ondansetron belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy.
Ondansetron works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
You are not recommended to take erythromycin with Ondansetron as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with Ondansetron.
Ondansetron may cause constipation as a side effect. It is not necessary for everyone taking Ondansetron to experience this side effect. However, if the condition persists or worsens, please consult a doctor.
Ondansetron should be used with caution in patients suffering from liver problems. However, inform your doctor if you have any liver problems before taking Ondansetron so that the dose may be adjusted appropriately.
Yes, Ondansetron may be used to prevent nausea and vomiting after surgery. Ondansetron blocks serotonin (a chemical) action which is responsible for causing nausea and vomiting.
Available Medicines for
Ondansetron
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