Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride
About Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride belongs to the group of anti-tuberculosis drugs, primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs but can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride combines four drugs: Isoniazid, Pyrazinamide, Pyridoxine hydrochloride (vitamin B6), and Rifampicin. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the bacterial cell wall. Pyrazinamide is an antibiotic that works by stopping the growth of bacteria that cause tuberculosis. Pyridoxine hydrochloride treats nerve damage (neuritis) caused by tuberculosis. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria.
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride is for paediatric use only. Give Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride to children as advised by the doctor. Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride may cause some common side effects such as muscle/joint pain, nausea, vomiting, rash, dark-coloured urine, weakness, dry mouth, stomach pain, and upset stomach. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.
Before using the Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride, please inform your doctor of your children's or caregiver's medical conditions, sensitivities, and all drugs they are taking. Continue using Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride for as long as your doctor has prescribed to treat your child's illness effectively. Do not use any other medications or supplements while using Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride unless recommended by the doctor.
Uses of Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride
• Treating Active TB: Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride helps treat TB infections in the lungs and other parts of the body in children.
• Preventing TB: It is used to stop latent TB from turning into active TB in children who may have been exposed to it.
• For High-Risk Children: Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride is given to children at high risk of developing TB, such as those with weakened immune systems.
• Combination Therapy: The combination of Isoniazid, Pyrazinamide, Pyridoxine hydrochloride (Vitamin B6), and Rifampicin works together to kill the bacteria causing TB.
Medicinal Benefits
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride contains a combination of Rifampicin, Isoniazid, Pyrazinamide, and Pyridoxine Hydrochloride, which are used to treat and prevent tuberculosis (TB). These medications work together to kill the bacteria causing TB and help stop its spread. Rifampicin and Isoniazid target the bacteria, while Pyrazinamide helps enhance the effectiveness of the other two. Pyridoxine is included to prevent nerve damage that Isoniazid could cause. This combination therapy helps manage the infection, reduce symptoms, and prevent the recurrence of TB.
Directions for Use
- Dissolve the tablet in the prescribed amount of water (usually a teaspoonful).
- Ensure the tablet is completely dissolved or dispersed in the water.
- Give the prepared solution to your child as directed by the doctor. Ensure your child drinks the solution after it is fully dispersed.
- Do not allow the child to crush, chew, or swallow the tablet whole.
Storage
Side Effects of Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride
- Muscle/joint pain
- Nausea
- Vomiting
- Rash
- Dark coloured urine
- Weakness
- Dry mouth
- Stomach pain
- Upset stomach
Drug Warnings
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride should be used only if prescribed by the doctor. The presence of other medical problems or the use of other medications may affect the use of this medicine. Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride is not recommended for those hypersensitive to any substance in Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride. So, before using Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride, let your doctor know about all your children's medical conditions, sensitivities, and all medications, including supplements used. Do not give more than the prescribed dose.
Drug Interactions
Drug-Drug Interactions: Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride may interact with antibiotics (erythromycin), pain killers (acetaminophen), anti-diabetic drugs (insulin isophane), anti-HIV drugs (saquinavir, ritonavir), supplements (ergocalciferol), gout medicines (probenecid, sulfinpyrazone), and oral contraceptives.
Drug-Food Interactions: Do not consume alcohol while taking Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride as they might cause interaction.
Drug-Disease Interactions: Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride may interact with colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, hemodialysis, diabetes, gout (high uric acid), liver toxicity, dialysis, optic neuritis (vision problems), kidney, and liver dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
not applicableIt is intended for Children.
Pregnancy
not applicableIt is intended for Children.
Breast Feeding
not applicableIt is intended for Children.
Driving
not applicableIt is intended for Children.
Liver
cautionPlease inform your doctor if your child has a history of Liver diseases. Your doctor will weigh the benefits and potential risks before prescribing Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride.
Kidney
cautionPlease inform your doctor if your child has a history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride.
Children
safe if prescribedRifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride is safe for children if prescribed by a doctor. The dose and duration may vary depending on the age and severity of the infection.
Habit Forming
Diet & Lifestyle Advise
- Alcohol can increase the risk of liver damage. To protect your liver, completely avoid alcohol during treatment.
- Some foods, especially those high in tyramine (like aged cheese, cured meats, and certain fish), can cause adverse reactions when combined with Isoniazid. Be mindful of what you eat and follow your doctor's advice.
- A well-balanced diet is key to boosting your immune system and helping your body recover. Focus on fruits, vegetables, whole grains, and lean proteins to stay healthy.
- Drink plenty of water throughout the day. This helps your kidneys work well and supports overall health during your treatment. Since these medications can affect liver function, make sure to have regular liver function tests as recommended by your doctor.
- Rifampicin can make your skin more sensitive to sunlight. Therefore, you should wear sunscreen and protective clothing and avoid prolonged sun exposure.
- To prevent drug resistance and ensure the medication works effectively, take the full course as prescribed by your doctor.
- Before changing your diet or lifestyle, always check with your doctor. They will guide you on what's best for your health during treatment.
Patients Concern
Disease/Condition Glossary
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease that can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or normal breathing, unexplained fatigue, fever, night sweats, and loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and those with immune system problems are at a higher risk of developing active TB.
FAQs
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride belongs to the group of medicines called anti-tuberculosis drugs, which are primarily used to treat and prevent tuberculosis.
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride contains Isoniazid, Pyrazinamide, Pyridoxine hydrochloride (vitamin B6), and Rifampicin. It interferes with the growth of tuberculosis-causing bacteria and kills them. Thus, Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride effectively treats TB (tuberculosis).
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride. Do not worry, as it is a common side-effect of Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride.
Common side effects may include muscle/joint pain, nausea, vomiting, rash, dark-coloured urine, weakness, dry mouth, stomach pain, and upset stomach. If these side effects become severe or persistent, consult your child’s doctor.
If you miss a dose, give it as soon as you remember, unless it’s almost time for the next dose. Never double the dose to make up for a missed one.
Yes, Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride can be taken with or without food. If your child experiences stomach discomfort, it may help to give them food.
The length of treatment will depend on your child’s condition. It’s important to complete the course as the doctor prescribes to ensure the infection is fully treated.
If your child vomits immediately after taking Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride, give the same dose again. If vomiting occurs after that time, skip the missed dose and continue with the next scheduled dose.
Available Medicines for
Rifampicin+isoniazid+pyrazinamide+pyridoxine Hydrochloride
