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THYROXINE is a synthetic thyroid hormone that works by replacing the thyroid hormone in the body when the natural production of thyroid hormones is not sufficient to meet the needs of the body. THYROXINE is primarily taken for treatment of hypothyroidism or low secretion of thyroid hormone. It comprises thyroxine which is a synthetic thyroid hormone that is chemically similar to thyroxine produced by our thyroid gland. Thyroxine helps to replace missing thyroid hormone and/or to relieve stress on the thyroid gland.

Hypothyroidism is a chronic condition in which our thyroid gland (located below the throat in the neck) is not able to produce enough thyroid hormone. Thyroid hormones are composed of tri-iodothyronine (T3) and thyroxine (T4) which controls the body's metabolism. In the condition of underactive thyroid body’s metabolism slows down and the person feels less energetic. Other symptoms include easy fatiguability, constipation, weight gain, feeling cold even in warm weathers, dry skin or too much or too fewer menses (in women) or even low mood. Treatment of hypothyroid is essential to restore the normal body metabolism (basal metabolic rate).

If you are experiencing any of the above symptoms, your doctor will advise you to undertake a blood test called 'thyroid function test' which checks three hormones related to thyroid - TSH, T3, T4. High TSH and low T3/T4 indicates that your thyroid gland is not functioning normally. The dose of THYROXINE is adjusted by your doctor on the basis of your body weight and thyroid function test report. It may take some weeks for the medicine to fully show its effects. Regular monitoring of thyroid function is advised to ensure that you receive the optimum dose of THYROXINE.

Take THYROXINE as prescribed by your doctor. THYROXINE usually does not have major side effects when taken regularly in the prescribed dosage but, overdosage may cause headache, nervousness, sleeplessness, irritability, diarrhoea, muscle spasm, weight loss, feeling hot even in cool environments, menstrual irregularities (in women), and skin rash. If you missed a dose do not take a double dose as it may produce serious side effects.

Your doctor may prescribe calcium or vitamin D supplements alongside THYROXINE for your bone health. THYROXINE should not be used for the purpose of weight loss alone. People affected with diabetes taking THYROXINE may have altered blood glucose control that may result in increased antidiabetic agents or insulin requirements. Hence, it is recommended that people with diabetes should contact a doctor and carefully monitor their glucose level after starting, changing, or discontinuing thyroid hormone therapy.


Hypothyroidism (underactive thyroid)

Medicinal Benefits

THYROXINE controls an underactive thyroid gland (hypothyroidism) and minimizes symptoms of low thyroid hormones like unknown weight gain, fatigue, sensitivity to the cold and many more. Thus, it helps in replacing the body's own natural thyroid hormone essential for maintaining both mental and physical health. However, THYROXINE should not be used for the treatment of weight loss or obesity.

Directions for Use

Swallow THYROXINE as a whole with water; do not crush, break or chew it.


Store in a cool and dry place away from sunlight

Side Effects of THYROXINE

  • Irregular heartbeat (palpitations)
  • Muscle spasm
  • Headache
  • Nervousness
  • Irritability
  • Sleeplessness
  • Tremors
  • Muscle weakness
  • Increased appetite
  • Weight loss
  • Diarrhoea
  • Heat intolerance
  • Menstrual irregularities
  • Skin rash

In-Depth Precautions and Warning

Drug Warnings

Foods like soybean flour, cottonseed meal, cabbage, cauliflower, walnuts, dietary fibre, calcium, and calcium-fortified juices may affect the working of THYROXINE. Hence, avoid the intake of these foods within several hours of dosing if possible. THYROXINE should not be administered to patients with acute myocardial infarction and high blood pressure patients. Close clinical monitoring of heart function is recommended before taking THYROXINE. Long term use of THYROXINE may affect your bone health leading to osteoporosis increasing the risk of bone fractures. Hence, your doctor may prescribe calcium or vitamin D supplements alongside THYROXINE for your bone health. THYROXINE should not be used for the purpose of weight loss alone. People affected with diabetes taking THYROXINE may have altered blood glucose control that may result in increased antidiabetic agents or insulin requirements. THYROXINE should is not recommended for the treatment of thyroid cancer and weight reduction.

Drug Interactions

Drug-Drug Interactions: Medicines like appetite suppressant (phentermine), acidity medicine (esomeprazole), anti-diabetic drug (metformin), calcium/vitamin D, and neuro-related medicine (amphetamine/dextroamphetamine), interact with THYROXINE. So, if you are taking these medicines make sure you contact your doctor before taking THYROXINE.

Drug-Food Interactions: If you are taking any homoeopathic, ayurvedic, Unani or any OTC items let your doctor know about this. These medicines may interact with THYROXINE and affect its working. Besides this, absorption of THYROXINE may be decreased by foods like soybean flour, cottonseed meal, walnuts, dietary fibre, calcium, and calcium-fortified juices. So, try to avoid these foods if possible.

Drug-Disease Interactions: Thyroid hormones increase the workload of the heart and oxygen consumption of the body. Hence, a THYROXINE should be taken with caution in the heart patients (cardiovascular disorders) like high blood pressure, chest pain (angina), and coronary artery disease. You should have regular monitoring of heart function. If chest pain occurs frequently contact the doctor so that doctor may reduce the dosage.

Drug-Drug Interactions Checker List:

  • Safety Advice

    • Safety Warning



      You are recommended not to consume alcohol along with THYROXINE to avoid unpleasant side effects.

    • Safety Warning


      safe if prescribed

      Only consume THYROXINE, if you are prescribed by a doctor. However, the need for Thyroxine may increase during pregnancy due to increased blood levels of oestrogen (female sex hormone) hence, monitoring of thyroid function should be done regularly both during and after pregnancy. In this case, the thyroid hormone dose can be adjusted by your doctor.

    • Safety Warning

      Breast Feeding


      Even during high-dose thyroxine therapy, the amount of THYROXINE passing into the breast milk during lactation is very low and therefore harmless. However, if you have any doubt consult a doctor.

    • Safety Warning


      safe if prescribed

      THYROXINE does not interfere with your ability to drive.

    • Safety Warning


      safe if prescribed

      THYROXINE does not have any reported interaction hence, in case you experience any difficulty discuss with your doctor.

    • Safety Warning


      safe if prescribed

      THYROXINE can be taken in the prescribed dose as it does not affects the kidney. However patient with adrenal gland complication or problem should consult a doctor before its intake.

    • Safety Warning


      safe if prescribed

      THYROXINE can be given to the children (new-borns and infants) with inborn thyroid hormone deficiency. To achieve normal mental and physical development, the initial recommended dosage is 10-15 mcg per kg/day for the first 3 months. After that doctor would adjust the dose individually according to the thyroid hormone level and TSH values measured in blood.

    Habit Forming


    Diet & Lifestyle Advise

    • Eating the right nutrients and taking a regular dose of your prescribed medications may help reduce your symptoms and improve your thyroid function. Iodine, zinc, and selenium are beneficial for people with hypothyroidism. However, it’s best to avoid iodine and selenium supplements unless your doctor advises you to take them.
    • In hypothyroidism usually, there is a loss of calcium (hypocalcemia) and Vitamin D in our body. In such a case, people affected with hypothyroidism should opt for calcium-enriched foods.
    • People with hypothyroidism usually have a slower metabolism and eating more protein may help boost your metabolism.
    • Daily yoga and aerobics exercises can help in boosting metabolism.
    • People with hypothyroidism should prefer the intake of more vegetables, fruits, and lean meats. These foods are low in calories and may help prevent weight gain.
    • Avoid taking Goitrogens (agents which interfere with the normal function of the thyroid gland) which generally includes soy foods (tofu), cabbage, broccoli, kale, cauliflower, spinach, sweet potatoes, cassava, peaches, strawberries, millet, pine nuts, peanuts, etc.

    Special Advise

    • Doses beyond the range of may produce serious or even life-threatening manifestations of toxicity. Thus, if you forget to take THYROXINE anytime, take the medicine as soon as you remember to take it. However, if it is almost time for your next dose, you make avoid the skipped dose and continue with your regular regime as advised by your doctor.
    • THYROXINE should not be used for the treatment of obesity or for weight loss.
    • Patients with adrenaline or pituitary gland problem, heart diseases, diabetes, clotting disorders should not take THYROXINE without consulting a doctor as the dose may need to be adjusted.
    • Diabetes patients taking THYROXINE should contact the doctor before starting this medicine as it may worsen glycaemic control and may result in increased antidiabetic pills or insulin therapy.
    • Regular intake of THYROXINE may decrease bone mineral density, particularly in post-menopausal women. Hence, consult your doctor who might prescribe you the lowest dose possible for your bone health.
    • If you are taking THYROXINE prior to any surgery let your doctor know about this.
    • Thyroid function tests are usually done on an empty stomach after overnight (6-8 hrs) fasting.

    Patients Concern

    Disease/Condition Glossary

    Hypothyroidism, or underactive thyroid, is a chronic condition when the thyroid gland does not make enough thyroid hormones to meet your body’s needs. When there is a low level of thyroid hormones, our body’s functions and metabolism slow down. Symptoms of hypothyroidism include tiredness, increased sensitivity to cold, constipation, dry skin, unexplained weight gain, puffy face, hoarseness of voice, and muscle weakness. There may be a loss of Calcium and Vitamin D in some cases of hypothyroidism.


    What is normal level of T3, T4 and TSH value in our body?

    Your thyroid hormone may vary depending on your age, sex, and condition (like pregnancy, chronic condition or complication). For example, a 30-year-old woman may have normal TSH around 4.2 mU/L, while a 90-year-old man may reach 8.9 mU/L at their upper limits. Besides this, your level of stress, diet, and medications, and menses period can fluctuate your level of thyroid hormone. An average general range for reference is as below: -Normal TSH range should be 0.4 - 4.0 mIU/L -Normal T3 range should be 0.2 - 0.5 ng/dl -Normal T4 range should be 0.8 - 1.8 ng/dl

    How will I know that I have hypothyroidism?

    If you observe symptoms like sudden weight gain, fatigue, increased sensitivity to cold, dry skin, constipation, puffy face, muscle weakness, anxiety, or voice hoarseness. You should consult an Endocrinologist/Physician for further treatment.

    Can I take THYROXINE with food?

    No. THYROXINE should be not be taken with food. Please take it empty stomach at least half an hour before tea/coffee/breakfast in the morning.

    How will I know that THYROXINE is working?

    You need to have a thyroid profile test which includes parameters like T3, T4 and TSH every month. You will observe a decrease in your TSH level after regular intake of THYROXINE as prescribed by your doctor.

    Can I take THYROXINE for weight loss?

    No. THYROXINE is only indicated for hypothyroidism and not for weight loss.

    How will I know that I have hypothyroidism?

    If you observe symptoms like sudden weight gain, fatigue, increased sensitivity to cold, dry skin, constipation, puffy face, muscle weakness, anxiety, or voice hoarseness. You should consult an Endocrinologist/Physician for further treatment.

    Do I have to limit my salt intake while taking THYROXINE?

    Yes. Limit salt intake to less than 2300 mg daily. Too much salt intake can increase your blood pressure especially when you have an underactive thyroid.

    Do I need to change the dose of THYROXINE if I become pregnant?

    Yes. Based on the thyroid profile test, an Endocrinologist may advise a pregnant woman to take a high dose of THYROXINE to meet the high-level thyroid hormone requirement. Treatment of underactive thyroid is vital during pregnancy, as low levels of thyroid hormone in the mother may harm both mother and baby.

    What if I miss a dose or I accidently take too much dose of THYROXINE?

    Do not take double doses in case you missed the dose of THYROXINE. If accidentally you have taken too much of THYROXINE, it may cause side effects like nervousness, insomnia, mild elevation of temperature, blood pressure elevation or loose stools. In this case, immediately contact the doctor and take only when your doctor has allowed you to take it.

    Can I stop taking THYROXINE on my own?

    No, endocrine disorders such as hypothyroidism is usually a lifelong condition. Stopping the medicine on your own can cause an imbalance in the body leading to very serious conditions affecting your metabolism.

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