Trimetazidine
About Trimetazidine
Trimetazidine is used to treat angina pectoris (chest pain caused by coronary disease) in adult patients in combination with other medications. Angina is chest pain, which happens when the heart does not receive an adequate supply of oxygen.
Trimetazidine contains Trimetazidine, which protects the heart cells from the effects of a reduced oxygen supply during an episode of angina.
Trimetazidine may cause side effects such as dizziness, headache, diarrhoea, vomiting, indigestion, abdominal pain, and nausea. If any of these side effects persist or worsen, consult your doctor.
Do not take Trimetazidine if you are allergic to any of its components. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your medical conditions and medications to prevent any potential interactions.
Uses of Trimetazidine
Medicinal Benefits
- Trimetazidine is used to treat angina pectoris (chest pain) in adult patients.
- It is indicated as an add-on therapy to relieve chest pain caused by reduced blood flow to the heart, especially in patients who do not respond well to or cannot tolerate first-line antianginal drugs.
- It helps preserve energy production in heart cells during episodes of low oxygen (ischemia), reducing damage caused by oxygen deprivation.
- Trimetazidine enhances the heart’s tolerance to stress by maintaining cellular function during oxygen shortages.
- It improves their physical activity levels and overall quality of life.
Directions for Use
- Take Trimetazidine with food or as advised by your doctor.
- Follow your doctor's instructions on the dosage and timing of this medication.
- Swallow Trimetazidine as a whole with a glass of water.
- Do not crush, chew or break it.
Storage
Side Effects of Trimetazidine
- Dizziness
- Headache
- Diarrhoea
- Vomiting
- Indigestion
- Abdominal pain
- Nausea
Drug Warnings
- Do not take Trimetazidine if you are allergic to any of its ingredients, or if you have Parkinson's disease, or severe kidney problems.
- Trimetazidine is not a cure for angina attacks, and should not be used as a treatment for unstable angina or heart attack.
- Inform your doctor if you have kidney or liver problems, close-angle glaucoma, trembling, rigid posture, slow movements, or a shuffling, unbalanced walk.
- Consult your doctor if you are pregnant or breast-feeding.
- In the event of an angina attack, tell your doctor, as your treatment may need to be re-evaluated.
- Trimetazidine is not recommended for children under 18.
- This medicine may cause dizziness, affecting your ability to drive.
- Let your doctor know if you are taking any other medications, including supplements or herbal products.
Drug Interactions
Drug-Drug Interactions: Inform your doctor if you are taking sedatives or hypnotics (buspirone), strong painkillers, allergy medications (chlorphenamine), antidepressants (fluoxetine, lithium), medicines to lower blood pressure (methyldopa), medicines to treat Parkinson’s disease (levodopa, pramipexole, ropinirole), medicines to treat epilepsy (phenobarbital, carbamazepine, phenytoin, rifampicin, primidone, oxcarbazepine, ethosuximide, valproate).
Drug-Food Interactions: No interactions found.
Drug-Disease Interactions: Inform your doctor if you have active liver disease, Parkinson's disease, or kidney impairment.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeTrimetazidine may cause dizziness when alcohol is taken. Therefore, avoid alcohol consumption.
Pregnancy
cautionPlease consult your doctor if you are pregnant.
Breast Feeding
cautionPlease consult your doctor if you are breastfeeding.
Driving
cautionTrimetazidine may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.
Liver
cautionTrimetazidine to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionTrimetazidine to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
unsafeTrimetazidine is not recommended for children below 18 years of age as the safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Eat a healthy diet rich in soluble fibre like beans, legumes, whole grains, flax, apples, and citrus fruits.
- Try to adopt a Mediterranean-style diet rich in olive oil, fruits, vegetables, nuts, whole grains, fish, and low in red meat and most dairy.
- Try to give priority to more fruits and veggies in your daily meals as these contain antioxidants.
- Minimise the intake of added sugar. The American Heart Association (ADA) recommends that one should not eat more than 100 calories (25 grams) of added sugar for women and children, and no more than 150 calories (37.5 grams) for men every day.
- The American Heart Association recommends that sodium chloride intake (table salt) should not exceed 2,300 mg per day as part of a healthy eating pattern.
- As a precautionary measure, do not consume alcohol and quit smoking.
Patients Concern
Disease/Condition Glossary
Angina Pectoris: Angina is chest pain which happens when enough oxygen does not reach the heart. This can be due to obstruction in the pathway or narrowing of the blood vessels. Patients with angina often explain the chest pain as squeezing, tightening, or pressure in the chest. Other symptoms can be dizziness, sweating, heartburn, and difficulty breathing.
FAQs
Trimetazidine is used to prevent an attack of angina pectoris (chest pain caused by coronary disease) in adult patients in combination with other medications.
Trimetazidine decreases the body's oxygen requirement by shifting metabolism from fats to glucose, increasing the rate at which glucose is broken down. Hence, the heart works efficiently and requires less oxygen.
No, Trimetazidine does not stop acute attacks (sudden attack) of angina. Trimetazidine helps prevent a new attack.
Usually, Trimetazidine is prescribed for long-term treatment ranging from weeks to months for treating heart-related conditions and disorders. However, taking it on your own for years without a doctor's consent can be fatal. Hence, only take it as long as your doctor has prescribed it to you.
No, Trimetazidine should not be stopped even if you feel better, as it worsens your condition. Please consult your doctor if you feel better and do as advised.
Yes, Trimetazidine can cause drowsiness. If you feel excessively sleepy, please consult your doctor for better advice.
Trimetazidine should be used with caution in elderly patients. Please consult the doctor before using Trimetazidine before using Trimetazidine in geriatric patients.
Trimetazidine is not recommended for use in children. Please consult the doctor if you have any concerns.
No, Trimetazidine may not cause weight gain. Follow a healthy diet and exercise regularly to maintain proper weight.
No, Trimetazidine is not a beta blocker. It is an anti-anginal medicine.
Trimetazidine should not be taken by people who are allergic to any of its components. Inform the doctor if you have severe kidney disease or Parkinsons disease.
Trimetazidine might increase the risk of falling due to a drop in blood pressure or instability while walking. Be cautious while getting up from a sitting/lying position.
Trimetazidine should be swallowed as a whole with water; do not crush or chew it.
The possible side effects of Trimetazidine are dizziness, headache, diarrhoea, vomiting, indigestion, abdominal pain, and feeling sick. In case of any discomfort, speak with a doctor.
