Yes, taking Sertraline 50 mg long-term is generally considered safe and is a common approach for managing chronic anxiety. Many patients take it for decades with well-tolerated results. However, because you have been on it for 12 years, it is important to have regular annual reviews with your doctor. These check-ups ensure the medicine remains effective and allow your physician to monitor for any potential long-term issues, such as changes in bone density or sodium levels. Please do not stop taking this medication or change your dosage without consulting your doctor, as sudden discontinuation can lead to withdrawal symptoms.