Leukoplakia is a chronic condition, and healing times vary. When using antioxidant supplements and a topical corticosteroid ointment, noticeable improvement or resolution is typically expected within 6 to 12 weeks. Since you have been using them for 45 days (about 6 weeks), you are at an important milestone to evaluate your progress. Complete healing also heavily depends on eliminating underlying irritants like tobacco, alcohol, or dental friction. I highly recommend scheduling a follow-up appointment with your doctor or dentist now. They can examine the area to determine if the treatment is working effectively or if further steps are needed to ensure it heals safely.