Sofradex-F cream is a combination medicine containing antibiotics and a mild corticosteroid, used to treat skin infections accompanied by inflammation. If you need a substitute, you can ask your doctor for topical creams containing similar generic active ingredients. Suitable alternatives include formulations that combine an antibiotic (such as framycetin, neomycin, or gentamicin) with a corticosteroid (such as fludrocortisone, dexamethasone, or hydrocortisone). These generic combinations work similarly to clear bacterial infections while soothing redness, itching, and swelling. Please consult your doctor to prescribe the most appropriate generic alternative for your specific skin condition.