An injection of methylprednisolone (a strong anti-inflammatory steroid) can be very effective for temporarily reducing severe bone pain, swelling, and nerve pressure, but because 500 mg is a high dose, it must be carefully supervised by a physician. Radiation therapy is also a highly advisable and standard treatment for localized bone pain. It works by targeting the specific painful area to shrink abnormal cells and provide significant, lasting relief. Both of these treatments are common and effective options for managing pain, but they require a confirmed diagnosis and a personalized plan from an oncologist to ensure they are used safely and effectively.