While mild skin sensitivity can occasionally occur with progesterone (Susten), generalized itching is not a typical side effect. In the third trimester, widespread itching?particularly on your palms and soles?can sometimes indicate a pregnancy-related liver condition called intrahepatic cholestasis of pregnancy. While this is not an emergency, it does warrant a prompt, reassuring evaluation by your obstetrician to ensure you and your baby remain safe and healthy. Please consult your doctor soon so they can run simple tests and help find you some relief.