You are taking duloxetine, clonazepam, and pregabalin, which work together to manage pain, anxiety, and mood. If symptoms like low mood and poor sleep persist, it could mean the current dosages need optimization, your body needs more time to adjust, or this specific combination isn't targeting the right chemical pathways for you. During your next visit, discuss with your doctor whether to adjust the doses of duloxetine or pregabalin, transition to a different class of antidepressant, add cognitive behavioural therapy (CBT) for sleep and mood, or screen for underlying vitamin deficiencies or thyroid issues.