An increase in your PSA after 8 years suggests the prostate cancer may be adapting to bicalutamide. This is a common and manageable step in long-term treatment, so please do not panic; many excellent alternative options exist. Your oncologist will likely recommend updated scans and a testosterone blood test to evaluate the situation. Next-step treatments often include switching to next-generation hormone therapies like abiraterone, enzalutamide, or apalutamide. Sometimes, simply stopping bicalutamide can temporarily decrease PSA. Other options include chemotherapy or immunotherapy. Please consult your oncologist soon to discuss which of these personalised therapies is best for you.