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  5. I had two surgeries for pepliary carcinoma of the thyroid. I last had surgery in May of 2015. Nuclear medicine and iodine therapy have been used to treat me. However, TG is still on the upper side (200+), so what may be the cause?

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I had two surgeries for pepliary carcinoma of the thyroid. I last had surgery in May of 2015. Nuclear medicine and iodine therapy have been used to treat me. However, TG is still on the upper side (200+), so what may be the cause?

Asked by Female, 40 · 4 days ago

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

4 days ago

Thyroglobulin (TG) is utilised as a tumour marker following therapy for Papillary Thyroid Carcinoma; a TG level above 200 may occasionally indicate residual thyroid tissue, recurrent disease, or the dissemination of thyroid cancer cells elsewhere in the body. Only after examining your scans, iodine uptake data, antibodies, and follow-up studies will the precise cause become clear. Because additional imaging, repeat iodine scans, PET scans, or extra medication may occasionally be required, ongoing follow-up with your endocrinologist or nuclear medicine specialist is crucial. Please don't panic, but do continue to receive specialised treatment and routine monitoring.
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What does an elevated thyroglobulin level mean for me?Could residual thyroid tissue cause my high TG level?What imaging tests will check for cancer recurrence?How often should I have my TG levels tested?Can anti-thyroglobulin antibodies affect my test results?

The patient has a history of papillary carcinoma of the thyroid treated with two surgeries (the last in May 2015), nuclear medicine, and iodine therapy. The current thyroglobulin (TG) level is elevated at 200.

🩺 Patient's Medical History Regarding Papillary Carcinoma of the Thyroid

The patient underwent two surgeries for papillary thyroid carcinoma with the most recent surgery in May 2015. Post-surgical treatments included nuclear medicine and radioactive iodine therapy to target any remaining thyroid tissue or cancer cells.

🩻 Explanation of Thyroglobulin (TG) and Its Significance

Thyroglobulin is a protein produced by thyroid cells, and after thyroid cancer treatment, TG is used as a tumor marker. An elevated TG level often suggests remaining or recurrent thyroid tissue or cancer.

⚠️ Possible Causes of Elevated TG Level (200)

  • Residual thyroid tissue or incomplete removal during surgery
  • Recurrence or metastasis of thyroid cancer
  • Interference from anti-thyroglobulin antibodies (rare) which can falsely elevate or lower TG values

🩺 Recommended Next Steps

  • Consult an Endocrinologist for detailed evaluation
  • Imaging studies such as neck ultrasound or radioactive iodine scans to check for residual or recurrent disease
  • Repeat TG levels with anti-thyroglobulin antibody testing to confirm results
  • Possible biopsy if suspicious lesions are found

Close follow-up with a specialist experienced in thyroid cancer management is essential to interpret TG and plan appropriate investigations and treatment.

Answered 4 days ago

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