If acne and hyperpigmentation persist despite treatment, it may indicate the need to review the medicines or doses, or to add targeted skin therapies. Consult a dermatologist to adjust treatment, rule out triggers, and plan proper acne control and pigmentation care.

If pimples have not reduced with Tretiva 20, treatment may need more time or a dose adjustment under medical supervision. You should follow up with your dermatologist, avoid stopping on your own, and continue prescribed skin care and blood tests as advised.