Hello. It is completely understandable to feel concerned about daytime fatigue. Yes, feeling extremely tired and sleepy is a very common side effect of Tryptomer 10mg (amitriptyline). This medication has a sedative effect, which often causes drowsiness, especially when starting it. Rejunex CD3, a nutritional supplement, is highly unlikely to cause this sleepiness. Please be reassured that this tiredness often improves as your body adjusts. To help, Tryptomer is typically taken at bedtime. I gently advise consulting your doctor before making any changes to your medication schedule. You are not alone, and this can be easily managed.