Some individuals taking Upnuron Tablet may experience bowel changes, including constipation, which in turn can worsen haemorrhoids due to straining. This effect is not universal, but the possibility exists. Maintaining adequate hydration and a fibre-rich diet can help reduce the likelihood of discomfort. As a precaution, patients with piles or chronic constipation should inform their physician before starting Upnuron so that treatment can be tailored appropriately and supportive measures or alternatives can be considered if needed.