For a venous ankle ulcer caused by varicose veins, medication alone is not enough. The most critical treatment is professional wound care and compression therapy (dressings and compression bandages), which must be managed by a doctor.To aid healing, your physician may prescribe venotonic medications like Pentoxifylline or Micronized Purified Flavonoid Fraction (MPFF). Antibiotics are only needed if the ulcer is actively infected (marked by increased redness, warmth, pain, or pus). For pain management, acetaminophen or ibuprofen can be used.\n\nPlease consult a vascular specialist or wound care clinic immediately to start a tailored treatment plan.