Localized Ewing sarcoma is highly treatable using a combination of chemotherapy, surgery, and radiation. Treatment typically begins with chemotherapy to shrink the tumor, followed by surgery or radiation, and concludes with further chemotherapy. The standard chemotherapy regimen (often called VDC-IE) alternates between two main drug combinations: 1. Vincristine, doxorubicin, and cyclophosphamide 2. Ifosfamide and etoposide. This multi-step approach is very effective at targeting the cancer. Your medical team will tailor this plan specifically to ensure the best possible care and support throughout your recovery.