Numbness and tingling in your hand while sleeping is usually caused by nerve compression (like carpal tunnel syndrome or a pinched nerve) due to your sleeping posture. There is no specific medication that instantly cures this. For symptom relief, over-the-counter anti-inflammatories (like ibuprofen) can reduce nerve inflammation, and Vitamin B-complex can support nerve health. However, the most effective initial steps are non-medicinal: avoid sleeping directly on that arm and try wearing a supportive wrist splint at night. Please consult a doctor for a proper physical examination to identify the exact cause before starting any long-term medication.