For mild to moderate knee pain, you can try over-the-counter pain relievers. Acetaminophen is effective for general pain relief. If there is swelling, oral nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen can help, but should be taken with food. Alternatively, a topical NSAID gel like diclofenac can be applied directly to the joint to reduce side effects. Along with medication, try resting, applying ice, and elevating your knee. Please consult a healthcare provider before starting new medications, especially if you have existing health conditions, or if the pain is severe, prevents you from bearing weight, or does not improve.