Voxyta Met 100/500 Tablet, which contains Metformin 500 mg and Sitagliptin 100 mg, is generally well tolerated. Some individuals may experience mild digestive side effects, such as gas, bloating, or stomach discomfort, when starting the medication or adjusting the dose, particularly with Metformin. These effects usually improve as the body adapts, and Sitagliptin rarely causes such issues. If these symptoms persist or become bothersome, it is essential to consult your doctor for advice.