To confirm whether this is a true polymyositis relapse or temporary weakness, your doctor will typically recommend the following investigations: Blood Tests: Measuring muscle enzymes like Creatine Kinase (CK) and aldolase. Elevated levels usually indicate active muscle inflammation. Muscle MRI: An MRI of your upper limbs can detect active muscle inflammation (oedema) and help distinguish a relapse from other causes. Electromyography (EMG): This measures electrical activity in the muscles to check for active myopathy It is also crucial to differentiate a relapse from steroid-induced muscle weakness (a side effect of Wysolone), which typically presents with normal CK levels. Please consult your rheumatologist to schedule these diagnostic tests.