As per the product label, Yesaka Liquid should be taken as 2 teaspoonfuls in the morning on an empty stomach and at bedtime. The label does not specify whether the bedtime dose should be taken before or after food. The appropriate timing may vary depending on the medical condition being treated, your individual medical needs, and any other medications you may be taking. Therefore, it is advisable to follow your physician's instructions regarding the bedtime dose.