It is best to take Zentel (albendazole) with a meal, especially one containing some fat, as this helps your body absorb the medicine better. You can safely take it during or after your menstrual period, as it does not interfere with your cycle. However, because albendazole should not be taken during pregnancy, it is always a good idea to ensure you are not pregnant before starting. Zentel is generally very well-tolerated. Some people might experience mild, temporary side effects like a slight headache, nausea, or mild stomach upset.