Taking sertraline and alprazolam together is generally safe when prescribed by your doctor, and they are often used together to manage anxiety. However, because both medications affect the central nervous system, combining them can increase side effects like drowsiness, dizziness, or lightheadedness. To stay safe, avoid alcohol, as it worsens these effects, and do not drive or operate machinery until you know how this combination impacts you. Always take them exactly as prescribed, and consult your doctor before making any changes or stopping the medication, to avoid withdrawal symptoms.