Muscle cramps after taking Zoryl-M 0.5 can happen in some people, often due to low sugar levels or electrolyte imbalance. Do not stop the medicine on your own. There is no single best medicine for type 2 diabetes; treatment depends on your sugar levels, age, weight, and other health conditions. Your doctor may adjust the dose or switch to another diabetes medicine that suits you better. Please consult your doctor for review.