It is wonderful that your blood sugar has come down from 350 to 167, but this significant drop can cause temporary symptoms as your body adjusts. The heaviness around your eyes is often a harmless sign of this transition. Bedwetting is not a common side effect of Zoryl M (glimepiride/metformin) or Jalra M (vildagliptin/metformin). However, rapid blood sugar changes can affect your sleep cycles or cause mild nighttime low blood sugar, which might contribute to bedwetting. I encourage you to check your blood sugar before bedtime and share these changes with your doctor to safely fine-tune your treatment.

While a blood sugar of 90 mg/dL is generally stable, his symptoms of confusion, weakness, and restlessness require prompt medical attention, especially after stopping essential medications like Ecosprin 75 AV, Forxiga, and Urimax F. In a 92-year-old recovering from COVID-19, these symptoms can indicate dehydration, electrolyte imbalances, or the sudden pause of his heart therapies. Please contact his doctor immediately for an urgent evaluation and blood tests to safely adjust his treatment plan. In the meantime, keep him well-hydrated and offer small, frequent meals.

Zoryl M2 is a combination of two active generic medicines: glimepiride and metformin. If you need an alternative, your doctor might suggest taking these two generic medications as separate tablets. Other effective generic alternatives in the same class include combinations of metformin with gliclazide, or metformin with sitagliptin. Please consult your doctor before making any changes, as they will safely tailor the prescription to your body's needs.

With a single kidney and long-standing diabetes, protecting your remaining kidney function is our absolute priority. Your current blood sugars are actually in a very reasonable range. I strongly advise against adding the herbal supplement IME9. Herbal formulations are not highly regulated and can contain ingredients that may strain your kidney. Additionally, combining it with your current medications, Rezonide Plus and Zoryl M2, could cause your blood sugar to drop too low. Please consult your doctor or nephrologist before starting any supplement to keep your kidney safe.

Your fasting sugar of 207 and post-meal sugar of 257 indicate that your current regimen of Megaliptin and Zoryl M4 Forte (which contains glimepiride and metformin) may need an adjustment. Our bodies' needs change over time, and it is very common to require medication updates. Please consult your doctor soon to safely review your dosages or discuss therapy adjustments. Meanwhile, continuing with a balanced, low-glycemic diet and regular light physical activity will help.

A continuous 36-hour water-only fast carries significant health risks given your medical history. Taking glimepiride/metformin (Zoryl M 1 Forte) while fasting can cause dangerously low blood sugar (hypoglycemia). Additionally, fasting and potential dehydration can strain your heart and affect how you tolerate aspirin/atorvastatin (Ecosprin AV 75). Please consult your doctor before starting; they can help adjust your medication schedule or suggest safer fasting alternatives that honor your traditions while protecting your heart and blood sugar.