Limited improvement is anticipated because Zyrtec is an antihistamine and is not a conventional treatment for psoriasis. Topical therapies, phototherapy, or systemic drugs given by a dermatologist are the most effective ways to manage psoriasis.

Zyrtec (cetirizine) may be insufficient for angioedema, particularly if swelling is severe or interferes with breathing, but it can help minimize moderate allergic responses and itching. Angioedema can be fatal, so get emergency medical assistance and heed your doctor's advise.