Dealing with hormonal acne from PCOS can be challenging, but you are on an excellent, comprehensive regimen. Typically, you can expect to see some improvement within 4 to 8 weeks, with significant clearing of your cheeks, jawline, and chin taking about 3 to 6 months. The oral medications?spironolactone (Aldactone) to target hormones and isotretinoin (Sotret) to prevent clogged pores?work powerfully from within. Meanwhile, your morning Faceclin gel and nightly Epiduo gel treat active breakouts and reduce inflammation on the surface. Consistency is key, and your skin will continue to improve over time. Please stay in close touch with your dermatologist to monitor your progress.