Please take your wife to the hospital immediately. An oxygen level dropping to 87%, especially during pregnancy, requires urgent medical evaluation to ensure both she and the baby are getting enough oxygen. While her daytime levels are 94-95% on the oxygen concentrator, these morning drops and severe shortness of breath mean her current home therapy is not sufficient. Hospitalization will allow doctors to safely monitor her asthma and COVID-19, adjust her medications like Medrol (methylprednisolone) and Budesal, and provide close monitoring for the baby. Please do not delay; seeking hospital care right away is the safest step for their well-being.

Since oral itraconazole and antihistamines weren't effective, the next best step is seeing a dermatologist. They can perform a skin scraping, culture, or biopsy to check for bacterial infections, atypical yeasts, or inflammatory conditions like inverse psoriasis. For relief, they might suggest drying solutions (like aluminum acetate), topical mild steroid creams, or non-steroidal anti-inflammatory topicals.

To help ease the pressure in your ears, a warm compress and nasal saline sprays can be very helpful. For the sore throat, warm saltwater gargles and staying well-hydrated work wonders. Over-the-counter pain relievers like paracetamol or ibuprofen can reduce discomfort. Since these symptoms are recurrent, it is highly recommended to see a healthcare professional. They can check for underlying causes like allergies or a sinus infection and guide you toward a lasting solution.

In older adults, itching on the hands, legs, and scalp is very common and often triggered by severe dry skin, though it can sometimes relate to nerve sensitivity or underlying medical conditions. While Cetaphil is a wonderfully gentle choice, daily fexofenadine (Allegra) should be approved by her doctor first. Fexofenadine is generally safer for seniors than older antihistamines, but we must ensure it is safe for her kidneys and won't interact with any other medications. I highly recommend having her evaluated by her physician or a dermatologist to help her find lasting comfort.

Since you are already taking Allegra (fexofenadine) alongside your antibiotics, MOX-CV (amoxicillin/clavulanate) and Kind 600, these new symptoms could be a mild allergic response or a simple viral cold. Please do not stop your antibiotics. I highly recommend contacting your prescribing doctor to report these symptoms. They can safely evaluate if any adjustments to your medication are needed. In the meantime, rest well and stay hydrated.

Since fexofenadine (Allegra) only provides temporary daily relief, we should focus on restoring your skin's natural moisture barrier. As we age, our skin naturally becomes drier and more sensitive. I recommend taking short, lukewarm showers instead of hot baths, and using a mild, soap-free cleanser. Immediately after gently patting dry, apply a generous amount of a thick, fragrance-free moisturizing cream to lock in hydration. If the itching persists despite these daily moisturizing steps, please consult your healthcare provider or a dermatologist to explore other potential causes and stronger, targeted treatments.