It is generally safe to receive the COVID-19 vaccine while taking Allegra (fexofenadine) and prednisolone. Fexofenadine will not interfere with the vaccine at all. However, because prednisolone is an oral steroid, it can sometimes lower your body's immune response, which might make the vaccine slightly less effective. It is still safe and highly recommended, but I suggest checking with your doctor to see if the timing of your vaccine should be coordinated with your daily prednisolone dose.
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Is it safe to get the COVID-19 vaccine while taking Allegra 120mg and prednisolone daily for allergies?