While both medications are generally well-tolerated, taking this combination daily for 10 years is something that should be carefully reviewed by your doctor. Over time, your allergy patterns may have changed, and long-term use of montelukast requires monitoring for any mood or sleep changes. I gently recommend scheduling an appointment with your healthcare provider or an allergist. They can safely evaluate your current symptoms, check your overall health, and help you determine if you can safely taper off or switch to a different management plan.

While Allegra 120 (fexofenadine) is designed to treat allergies, antihistamines can sometimes cause mild dryness in the throat, which can feel like an itchy or 'stuck' sensation. Alternatively, this could simply be a symptom of your underlying allergies or mild reflux. I suggest sipping some warm water to see if it helps soothe your throat. However, if you ever experience difficulty breathing, swelling, or worsening symptoms, please seek medical attention immediately. I recommend sharing this with your doctor to ensure you stay comfortable and safe.

Generally, these active ingredients are safe, even over several years. However, taking any medication for ten years warrants a review with your doctor. While major long-term risks are rare, montelukast can occasionally affect mood. It is best to consult your healthcare provider to see if you still need both ingredients daily. They might suggest transitioning to a single antihistamine like fexofenadine alone or using a generic steroid nasal spray, which are excellent, targeted alternatives.

What you are describing sounds like hives (urticaria). Since fexofenadine (Allegra) hasn't fully cleared them after three weeks, you may benefit from a dosage adjustment or combining it with another type of antihistamine. Sometimes, localized hives on the hands are triggered by friction, temperature changes, or stress. I highly recommend seeing a doctor or allergist. They can safely personalize your medication plan and help pinpoint any specific triggers. Please be reassured that this is very common, and with the right adjustment.

Allegra-M (fexofenadine and montelukast) is excellent for controlling your allergy symptoms, though it does not directly lower the IgE number in your blood. To help lower your IgE levels naturally, the best precaution is to identify and strictly avoid your allergy triggers, such as dust, pollen, or certain foods. I highly recommend consulting an allergist for a simple allergy test and to discuss long-term options like immunotherapy, which can safely help desensitize your immune system.

Since topical treatments like ketoconazole and Candid powder haven't worked, and the infection has spread, you likely require a prescription oral antifungal medication. The skin darkening you noticed is post-inflammatory hyperpigmentation, which is very common and will gradually fade once the infection is fully cleared. Please stop using the Ayurvedic remedies, keep the area clean and dry, wear loose cotton clothing, and consult a doctor or dermatologist for a targeted prescription plan to finally resolve this.