Allegra (fexofenadine) is a daily medication that typically wears off within 24 hours. Once the medicine leaves your system, the itching returns because the underlying cause of your reaction is still active. Since the itching is severe and keeps coming back, I highly recommend scheduling an appointment with your doctor or an allergist. They can help identify the root cause, safely adjust your daily dose of fexofenadine, or recommend other targeted treatments to give you lasting relief.
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Why does my severe full-body itching keep coming back two days after taking Allegra, and what should I do next?