Developing painful lumps (induration) at the injection site is a relatively common reaction to repeated intramuscular Streptomycin injections. It usually happens when medicine accumulates in the muscle tissue. To manage this, use a warm compress: Apply it to the area for 15-20 minutes a few times daily to improve blood flow and help dissolve the lump. Rotate Sites: Ensure your healthcare provider rotates the injection sites (alternating buttocks or thighs). Pain Relief: Over-the-counter paracetamol can help ease the discomfort. Please inform your doctor or nurse. They can inspect the lumps to rule out infection and suggest alternative injection techniques if needed.

Lower back and side pain is not a common direct side effect of streptomycin. However, because streptomycin can occasionally affect the kidneys, this pain could sometimes indicate kidney irritation. More commonly, since you are being treated for bone tuberculosis, the pain may actually be related to the infection itself, especially if it affects your spine or surrounding tissues. Please do not worry, but do contact your doctor promptly. They can easily run a simple blood test to check your kidney function and evaluate your back to ensure your tuberculosis treatment is progressing safely and effectively.