Generally, brief exposure to warmth won't instantly ruin your povidone-iodine (Betadine) gargle. However, active iodine can degrade under prolonged or extreme heat, which might lessen its effectiveness. To keep it working best, try to store it in a cool, dry place away from direct sunlight. A good rule of thumb is to check the liquid: if it still has its characteristic dark brown color and normal smell, it is likely safe and effective to use. If it looks faded or clear, it is best to replace it.
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