To manage pain and swelling during your root canal treatment, over-the-counter anti-inflammatory medications like ibuprofen are generally the most effective first-line option. If you cannot take ibuprofen, acetaminophen is a suitable alternative. For infection control, antibiotics are not always necessary and are only prescribed by your dentist if an active, spreading infection is present. You can safely prevent local irritation by gently rinsing with warm salt water and maintaining good oral hygiene. Please consult your treating dentist before starting any medication to ensure it is safe for your specific health history and to get the correct dosage recommendations.