After completing Deviry (medroxyprogesterone), it typically takes 2 to 10 days?and sometimes up to two weeks?for withdrawal bleeding to start. Since your pregnancy tests are negative, you can safely wait a few more days. Your severe vitamin D deficiency of 3 and low hemoglobin of 8 can absolutely contribute to delayed or absent periods, as your body requires adequate nutrient levels to maintain a regular menstrual cycle. I highly recommend discussing these lab results with your doctor to start appropriate iron and vitamin D treatments, which will support your overall health and help restore your regular cycle.

Bleeding typically starts 3 to 10 days after you finish taking your last dose of Deviry (medroxyprogesterone acetate), rather than during the course. Please give your body a few more days to respond. Your irregular periods and the 10-kilogram weight gain could indeed be linked. Hormonal imbalances, such as Polycystic Ovary Syndrome (PCOS) or thyroid issues, often cause both weight changes and irregular cycles. I highly recommend speaking with your doctor for a hormonal evaluation to help get you some answers and peace of mind.

While both medications are helpful, taking Deviry (medroxyprogesterone) and Trenexa (tranexamic acid) together can increase the risk of blood clots. More importantly, Trenexa is meant for heavy menstrual bleeding, not for bleeding from your bottom (rectal bleeding). Rectal bleeding can be caused by various issues like hemorrhoids or small tears, and it requires a proper medical evaluation rather than self-treatment. I gently advise against taking Trenexa for this bleeding. Please consult your doctor so they can safely examine you, find the exact cause of the bleeding, and prescribe the right treatment.

Managing your weight with PCOS while taking Deviry (medroxyprogesterone) can certainly feel challenging, but please be gentle with yourself. Since PCOS often causes insulin resistance, focusing on a balanced, low-glycemic diet rich in fiber and lean proteins can make a big change. Combining this with regular, enjoyable physical activity?especially a mix of strength training and cardiovascular exercise?helps improve your metabolism. Staying hydrated, prioritizing good sleep, and managing stress also play key roles in balancing your hormones. It is always a good idea to discuss these struggles with your doctor, who can check your insulin levels and help tailor a personalized plan.

Typically, you will experience a withdrawal bleed within 3 to 7 days after your last dose. Your normal menstrual cycle and ovulation should resume in the very next cycle. It is generally safe to start attempting conception once you have this first normal period, which also helps in accurately dating your pregnancy. There is no evidence of any harmful lingering effects on your future baby or fertility.

Since your blood and urine pregnancy tests are negative and your pelvic ultrasound is normal, pregnancy is highly unlikely. After finishing a course of Deviry (medroxyprogesterone), it is very common for your period to take anywhere from 3 to 14 days to start. Sometimes, minor hormonal shifts or everyday stress can cause a slight delay. Since your thyroid and blood sugar results are also perfectly normal, your body may just need a few more days to respond. Try to relax, and if your period does not arrive within another week, please reach out to your doctor for a gentle follow-up.