When considering taking Dolonex (Piroxicam) with high cholesterol, it's important to be cautious. Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that can sometimes affect heart and blood vessel health, especially if you have risk factors like high cholesterol.

• Consult your doctor first: Before taking Dolonex again, discuss your high cholesterol and any other health conditions with your doctor. They can assess your overall risk and decide if this medication is safe for you.

• Monitor for side effects: NSAIDs can increase blood pressure and may affect heart health, so if you do take it, watch for symptoms like chest pain, shortness of breath, or swelling.

• Alternative pain relief: Your doctor might suggest other pain management options that are safer given your cholesterol levels.

• Lifestyle and cholesterol control: Managing your cholesterol through diet, exercise, and medications as prescribed can also help reduce overall health risks.

In summary, while Dolonex can help with pain, your high cholesterol means you should use it cautiously and under medical supervision to ensure your safety and well-being. Please consult a specialist doctor, such as a cardiologist or your primary care physician, before resuming this medication.To narrow down potential causes, we will need some more information.I understand you're dealing with lower back and muscle pain, and you're wondering if you should take Dolonex again, especially with your high cholesterol. Could you please provide your age and gender?